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PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Bos taurus (cattle) ]

Gene ID: 282023, updated on 5-Jul-2015
Gene symbol
PTGS2
Gene description
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
See related
BGD:BT11819; Ensembl:ENSBTAG00000014127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
See PTGS2 in MapViewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
104 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 16 AC_000173.1 (69263775..69271833, complement)

Chromosome 16 - AC_000173.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104974510 Neighboring gene phosducin Neighboring gene histone H2B type 1-like Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prostaglandin G/H synthase 2
Names
COX-2
PGH synthase 2
PGHS-2
PHS II
cyclooxygenase-2
prostaglandin H2 synthase 2
NP_776870.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174445.2NP_776870.1  prostaglandin G/H synthase 2 precursor

    See identical proteins and their annotated locations for NP_776870.1

    Status: PROVISIONAL

    Source sequence(s)
    AF031698
    UniProtKB/Swiss-Prot
    O62698
    Related
    ENSBTAP00000018774, ENSBTAT00000018774
    Conserved Domains (3) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:122560
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1.1 Primary Assembly

Genomic

  1. AC_000173.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Range
    69263775..69271833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010813539.1XP_010811841.1  

    See identical proteins and their annotated locations for XP_010811841.1

    UniProtKB/TrEMBL
    F1MNI5
    Conserved Domains (3) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:122560
    An_peroxidase; Animal haem peroxidase
  2. XM_010813540.1XP_010811842.1  

    Conserved Domains (2) summary
    cd09816
    Location:43530
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam03098
    Location:90528
    An_peroxidase; Animal haem peroxidase

Alternate Btau_4.6.1

Genomic

  1. NC_007314.4 Alternate Btau_4.6.1

    Range
    65373125..65380748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)