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PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Bos taurus (cattle) ]

Gene ID: 282023, updated on 26-Aug-2014
Official Symbol
PTGS2
Official Full Name
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Locus tag
BOS_16112
See related
BGD:BT11819; Ensembl:ENSBTAG00000014127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
See PTGS2 in MapViewer
Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
103 current Bos_taurus_UMD_3.1 (GCF_000003055.4) 16 AC_000173.1 (69263776..69271399, complement)

Chromosome 16 - AC_000173.1Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame, human C1orf27 Neighboring gene phosducin Neighboring gene histone H2B type 1-like Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
COX-2
PGHS-2
PHS II
PGH synthase 2
cyclooxygenase-2
prostaglandin H2 synthase 2
NP_776870.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174445.2NP_776870.1  prostaglandin G/H synthase 2 precursor

    See proteins identical to NP_776870.1

    Status: PROVISIONAL

    Source sequence(s)
    AF031698
    UniProtKB/Swiss-Prot
    O62698
    Related
    ENSBTAP00000018774, ENSBTAT00000018774
    Conserved Domains (3) summary
    cd09816
    Location:75562
    Blast Score: 2117
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    Blast Score: 94
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:122560
    Blast Score: 1030
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

  1. AC_000173.1 

    Range
    69263776..69271399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007314.4 

    Range
    65373125..65380748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)