PPARA peroxisome proliferator-activated receptor alpha [Bos taurus (cattle)] - Gene

Summary

Go to the top of the page Help

Symbol: PPARA
Full Name: peroxisome proliferator-activated receptor alpha
Locus tag: BOS_6232
See related: BGD:BT10263; Ensembl:ENSBTAG00000008063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PPARalpha

Genomic context

Go to the top of the page Help

Location :: chromosome: 5

Sequence :: Chromosome: 5; AC_000162.1 (117150468..117233112)

See PPARA in MapViewer

Chromosome 5 - AC_000162.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that PPARalpha (but not PPARgamma) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Title: Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Title: Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 levels in bovine endometrial stromal cells.
Title: Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
Title: Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Title: Dietary trans octadecenoic acids upregulate the liver gene encoding peroxisome proliferator-activated receptor-alpha in transition dairy cows.

Submit: New GeneRIF Correction

Pathways from BioSystems

Go to the top of the page Help

Activation of Gene Expression by SREBP (SREBF), organism-specific biosystem (from REACTOME)
Activation of Gene Expression by SREBP (SREBF), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem (from REACTOME)
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Circadian Repression of Expression by REV-ERBA, organism-specific biosystem (from REACTOME)
Circadian Repression of Expression by REV-ERBA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nuclear Receptors, organism-specific biosystem (from WikiPathways)
Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RORA Activates Circadian Expression, organism-specific biosystem (from REACTOME)
RORA Activates Circadian Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Cholesterol Biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
Regulation of Cholesterol Biosynthesis by SREBP (SREBF), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Homology

Homologs of the PPARA gene: The PPARA gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, and zebrafish.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

General protein information

Go to the top of the page Help

Preferred Names: peroxisome proliferator-activated receptor alpha

Names: peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034036.1 → NP_001029208.1 peroxisome proliferator-activated receptor alpha

Status: PROVISIONAL

Source sequence(s)

BT020756

UniProtKB/TrEMBL

Q5EA13

Related

ENSBTAP00000010606, ENSBTAT00000010606

Conserved Domains (2) summary

cd06932
Location:203 – 469
Blast Score: 995

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:103 – 186
Blast Score: 465

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Build 6.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

AC_000162.1 Reference Bos_taurus_UMD_3.1 Primary Assembly

Range

117150468..117233112

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

NC_007303.5 Alternate Btau_4.6.1

Range

122731123..122801425

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAFC03023187.1	None
genomic	AAFC03028235.1	None
genomic	AAFC03028237.1 (29445..35805)	None
genomic	AAFC03028238.1	None
genomic	DAAA02014949.1 (19..24648)	None
genomic	DAAA02014950.1	None
genomic	DAAA02014951.1	None
genomic	DAAA02014952.1	None
genomic	GJ060870.1	DAA29024.1	Hereford
genomic	Y09724.1	None
mRNA	AF229356.1	AAF73405.1
mRNA	BT020756.1	AAX08773.1