MMP1 matrix metallopeptidase 1 (interstitial collagenase) [Bos taurus (cattle)] - Gene

Summary

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Symbol: MMP1
Full Name: matrix metallopeptidase 1 (interstitial collagenase)
Locus tag: BOS_14255
See related: BGD:BT11280; Ensembl:ENSBTAG00000015818
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MMP-1
Annotation information: Annotation category: partial on reference assembly

Genomic context

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Location :: chromosome: 15

Sequence :: Chromosome: 15; AC_000172.1 (6132916..6141316)

See MMP1 in MapViewer

Chromosome 15 - AC_000172.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB
Title: Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
Title: Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.
In cervix, MMP1 is only active during the final cervical ripening process at parturition.
Title: MMP-2 expression precedes the final ripening process of the bovine cervix.
IL-4 and IL-13 affect airway smooth muscle (SM) gel contraction via a phosphatidylinositol 3-kinase mediated endogenous production of MMP-1 that alters the interaction between SM cells and collagen fibers.
Title: Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production.
MT1-MMP has a role in signaling events mediating EGFR transactivation
Title: Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation.
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (follicular apex vs. base) for the preovulatory collagenolysis required for follicle rupture
Title: Gonadotropin surge-induced differential upregulation of collagenase-1 (MMP-1) and collagenase-3 (MMP-13) mRNA and protein in bovine preovulatory follicles.
the differential expression and localization of membrane-type 1 matrix metalloproteinase in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2
Title: Bovine membrane-type 1 matrix metalloproteinase: molecular cloning and expression in the corpus luteum.
identification of MT1-MMP in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface
Title: Expression of MT1-MMP during deciduous tooth resorption in odontoclasts.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
Activation of Matrix Metalloproteinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Basigin interactions, organism-specific biosystem (from REACTOME)
Basigin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Bladder cancer, organism-specific biosystem (from KEGG)
Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Bladder cancer, conserved biosystem (from KEGG)
Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of collagen, organism-specific biosystem (from REACTOME)
Degradation of collagen, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...

General gene information

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Markers

MMP7 (e-PCR)
- UniSTS:278784

MMP1 (e-PCR)
- UniSTS:273431

PMC65699P1 (e-PCR)
- UniSTS:273431

Homology

Homologs of the MMP1 gene: The MMP1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
collagen catabolic process	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interstitial collagenase

Names: interstitial collagenase; fibroblast collagenase; matrix metalloproteinase-1

NP_776537.1

EC 3.4.24.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174112.1 → NP_776537.1 interstitial collagenase precursor

Status: PROVISIONAL

Source sequence(s)

X58256

UniProtKB/Swiss-Prot

P28053

Related

ENSBTAP00000046488, ENSBTAT00000049622

Conserved Domains (3) summary

cd00094
Location:275 – 466
Blast Score: 578

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:109 – 261
Blast Score: 566

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:27 – 87
Blast Score: 140

PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Build 6.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

AC_000172.1 Reference Bos_taurus_UMD_3.1 Primary Assembly

Range

6132916..6141316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

NC_007313.5 Alternate Btau_4.6.1

Range

4752100..4784226

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAFC03013362.1 (25659..34863)	None
genomic	AAFC03013364.1 (31160..36486)	None	Hereford
genomic	AAFC03053023.1 (2111..19655)	None
genomic	AF342725.1	None
genomic	DAAA02039869.1	None
genomic	GJ062385.1	DAA22470.1	Hereford
mRNA	AF134714.1	AAD30274.1
mRNA	X58256.1	CAA41210.1