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GP2 glycoprotein 2 [ Homo sapiens (human) ]

Gene ID: 2813, updated on 8-May-2016
Official Symbol
GP2provided by HGNC
Official Full Name
glycoprotein 2provided by HGNC
Primary source
HGNC:HGNC:4441
See related
Ensembl:ENSG00000169347 HPRD:04279; MIM:602977; Vega:OTTHUMG00000131489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP75
Summary
This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Orthologs
Location:
16p12
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (20309574..20327820, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20320896..20339684, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723396 Neighboring gene small nuclear ribonucleoprotein polypeptide E pseudogene 3 Neighboring gene uromodulin Neighboring gene protein disulfide isomerase like, testis expressed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis identifies common variants associated with body mass index in east Asians.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog
New loci associated with kidney function and chronic kidney disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp779K0533

Gene Ontology Provided by GOA

Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pancreatic secretory granule membrane major glycoprotein GP2
Names
glycoprotein 2 (zymogen granule membrane)
pancreatic zymogen granule membrane associated protein GP2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007240.2NP_001007241.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001007241.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC106796, AK293384, BX647831, DA041213
    Consensus CDS
    CCDS42128.1
    UniProtKB/Swiss-Prot
    P55259
    UniProtKB/TrEMBL
    B7Z1G2
    Related
    ENSP00000370767, OTTHUMP00000256656, ENST00000381362, OTTHUMT00000436920
    Conserved Domains (1) summary
    smart00241
    Location:229480
    ZP; Zona pellucida (ZP) domain
  2. NM_001007241.2NP_001007242.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001007242.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC106796, AK293384
    Consensus CDS
    CCDS45433.1
    UniProtKB/TrEMBL
    B7Z1G2
    Related
    ENSP00000370765, OTTHUMP00000256657, ENST00000381360, OTTHUMT00000436921
    Conserved Domains (1) summary
    smart00241
    Location:82333
    ZP; Zona pellucida (ZP) domain
  3. NM_001007242.2NP_001007243.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001007243.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The resulting protein (isoform 4, also known as beta) is shorter than isoform 1.
    Source sequence(s)
    AC106796, AK293384, BX648201, DA041213
    Consensus CDS
    CCDS45432.1
    UniProtKB/TrEMBL
    B7Z1G2
    Related
    ENSP00000343861, OTTHUMP00000256655, ENST00000341642, OTTHUMT00000436919
    Conserved Domains (1) summary
    smart00241
    Location:79330
    ZP; Zona pellucida (ZP) domain
  4. NM_001502.3NP_001493.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001493.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2, also known as alpha) is shorter than isoform 1.
    Source sequence(s)
    AC106796, AK293384, CR749600, DA041213
    Consensus CDS
    CCDS10582.2
    UniProtKB/Swiss-Prot
    P55259
    UniProtKB/TrEMBL
    B7Z1G2, Q68D34
    Related
    ENSP00000304044, OTTHUMP00000162214, ENST00000302555, OTTHUMT00000254335
    Conserved Domains (1) summary
    smart00241
    Location:226477
    ZP; Zona pellucida (ZP) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    20309574..20327820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545797.1XP_011544099.1  

    See identical proteins and their annotated locations for XP_011544099.1

    UniProtKB/TrEMBL
    B7Z1G2
    Conserved Domains (1) summary
    smart00241
    Location:207458
    ZP; Zona pellucida (ZP) domain

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    20408792..20426837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)