MSTN myostatin [Bos taurus] - Gene

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Summary

Symbol: MSTN
Full Name: myostatin
Primary source: BGD:BT12005
Locus tag: BOS_1535
See related: Ensembl:ENSBTAG00000011808
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GDF8

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Genomic context

Location :: 2q14-q15

Sequence :: Chromosome: 2; AC_000159.1 (6213566..6220196)

See MSTN in MapViewer

Chromosome 2 - AC_000159.1 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expressions of C-EBPalpha and myostatin in muscles were higher in the concentrate-fed group than in the grass hay-fed group.
Title: Influence of different feeding systems on the growth performance and muscle development of Japanese Black steers.
The sequence of the bovine myostatin gene promoter and first intron from Qinchuan and Red Angus cattle, was analyzed.
Title: Molecular analysis of the first intron in the bovine myostatin gene.
the selection of the myostatin gene "+" allele has the potential to increase conventional milk production traits in the dual-purpose Belgian Blue breed.
Title: Short communication: influence of the muscle hypertrophy mutation of the myostatin gene on milk production traits and milk fatty acid composition in dual-purpose Belgian Blue dairy cattle.
The I442M mutation in the NCAPG gene and the Q204X mutation in the GDF8 gene, were identified as substantial modulators of pre- and/or postnatal growth in cattle.
Title: Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition.
extracellular matrix molecules may modulate myostatin activity
Title: Interaction between myostatin and extracellular matrix components.
mutations Q204X and nt821 affect carcass and meat quality
Title: The two mutations, Q204X and nt821, of the myostatin gene affect carcass and meat quality in young heterozygous bulls of French beef breeds.
The gene expression pattern of inhibitory proteins related to MSTN signaling suggests a strong downregulation of this pathway in response to prolonged stretching.
Title: Expression of genes related to myostatin signaling during rat skeletal muscle longitudinal growth.
DNA sequencing revealed three, seven and four polymorphisms in exons 1, 2 and 3, respectively of the myostatin gene.
Title: Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle.
The objective of this study was to quantify the effects of the Charolais-specific inactive myostatin allele on phenotypic means and genetic parameters of heifer breeding traits.
Title: Genetic analysis of breeding traits in a Charolais cattle population segregating an inactive myostatin allele.
11-bp deletion in the bovine myostatin was found at a low frequency (0.04) with no animals homozygous for the mutation in the sample population (536 animals)in a commercial population of Scottish Aberdeen Angus beef cattle.
Title: Associations between the 11-bp deletion in the myostatin gene and carcass quality in Angus-sired cattle.

Submit: New GeneRIF Correction See all (17)

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Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
growth	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: growth/differentiation factor 8

Names: growth/differentiation factor 8; GDF-8; growth differentiation factor 8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001525.2 → NP_001001525.1 growth/differentiation factor 8 precursor

Status: PROVISIONAL

Source sequence(s)

AF320998

UniProtKB/TrEMBL

C6KEF7

UniProtKB/Swiss-Prot

O18836

Related

ENSBTAP00000015674, ENSBTAT00000015674

Conserved Domains (2) summary

pfam00688
Location:33 – 256
Blast Score: 398

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:281 – 375
Blast Score: 391

TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Build 6.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

AC_000159.1 Reference Bos_taurus_UMD_3.1 Primary Assembly

Range

6213566..6220196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

NC_007300.5 Alternate Btau_4.6.1

Range

6538211..6544838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AB076403.1	BAB79498.1
genomic	AB232688.1	BAE20190.1	Japanese Black
genomic	AB232689.1	BAE20191.1	Japanese Black
genomic	AB232690.1	BAE20192.1	Japanese Black
genomic	AB232691.1	BAE20193.1	Japanese Black
genomic	AB232692.1	BAE20194.1	Japanese Black
genomic	AF320998.1	AAG48116.1
genomic	AF348479.1	AAK31160.1
genomic	AJ310751.2	None
genomic	AJ438578.1	CAD27441.1
genomic	AY725215.1	AAU25948.1
genomic	AY850105.1	AAX51855.1	Beefmaster
genomic	EF467376.1	ABP36012.1	Mongolia
genomic	EF467377.1	ABP36013.1	Mongolia
genomic	EF467378.1	ABP36014.1	Mongolia
genomic	EF467379.1	ABP36015.1	Mongolia
genomic	EF467380.1	ABP36016.1	Mongolia
genomic	EF467381.1	ABP36017.1	Mongolia
genomic	EF467382.1	ABP36018.1	Mongolia
genomic	EF467383.1	ABP36019.1	Mongolia
genomic	EF467384.1	ABP36020.1	Mongolia
genomic	EF467385.1	ABP36021.1	Mongolia
genomic	EF467386.1	ABP36022.1	Mongolia
genomic	EF467387.1	ABP36023.1	Mongolia
genomic	EF467388.1	ABP36024.1	Mongolia
genomic	EF467389.1	ABP36025.1	Mongolia
genomic	EF467390.1	ABP36026.1	Mongolia
genomic	EF467391.1	ABP36027.1	Mongolia
genomic	EF467392.1	ABP36028.1	Mongolia
genomic	EF467393.1	ABP36029.1	Mongolia
genomic	FJ752671.1	ACN65828.1	Menggu
genomic	FJ752672.1	ACN65829.1	Menggu
genomic	GJ060531.1	DAA32858.1	Hereford
genomic	HC889208.1	CBM42952.1
mRNA	AF019620.1	AAB86687.1
mRNA	AF019761.1	AAB81508.1
mRNA	AY160688.1	AAN65183.1
mRNA	BC134563.1	AAI34564.1	L1 Hereford
mRNA	GQ184147.1	ACS70961.1	Bohai Black

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O18836.2	GenPept	UniProtKB/Swiss-Prot:O18836
Q401B2	GenPept	UniProtKB/TrEMBL:Q401B2
Q401B4	GenPept	UniProtKB/TrEMBL:Q401B4
Q401B6	GenPept	UniProtKB/TrEMBL:Q401B6
Q645Q7	GenPept	UniProtKB/TrEMBL:Q645Q7
Q8SPM3	GenPept	UniProtKB/TrEMBL:Q8SPM3
Q9BDK1	GenPept	UniProtKB/TrEMBL:Q9BDK1