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EDN1 endothelin 1 [ Bos taurus (cattle) ]

Gene ID: 281137, updated on 12-Apr-2014
Symbol
EDN1
Full Name
endothelin 1
Locus tag
BOS_22048
See related
BGD:BT10530; Ensembl:ENSBTAG00000008096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Location :
chromosome: 23
Sequence :
Chromosome: 23; AC_000180.1 (44010442..44017425, complement)
See EDN1 in MapViewer

Chromosome 23 - AC_000180.1Genomic Context describing neighboring genes Neighboring gene multidrug resistance-associated protein 4-like Neighboring gene phosphatase and actin regulator 1 Neighboring gene filamin-binding LIM protein 1-like Neighboring gene human immunodeficiency virus type I enhancer binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
endothelin A receptor binding IEA
Inferred from Electronic Annotation
more info
 
endothelin B receptor binding IEA
Inferred from Electronic Annotation
more info
 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
body fluid secretion IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
glucose transport IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
neural crest cell development IEA
Inferred from Electronic Annotation
more info
 
nitric oxide transport IEA
Inferred from Electronic Annotation
more info
 
patterning of blood vessels IEA
Inferred from Electronic Annotation
more info
 
peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
phospholipase D-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prostaglandin-endoperoxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
protein kinase C deactivation IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
regulation of pH IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by endothelin IEA
Inferred from Electronic Annotation
more info
 
regulation of vasoconstriction NAS
Non-traceable Author Statement
more info
PubMed 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
rhythmic excitation IEA
Inferred from Electronic Annotation
more info
 
vein smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
endothelin-1
Names
endothelin-1
ET-1
PPET1
preproendothelin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181010.2NP_851353.1  endothelin-1 precursor

    See proteins identical to NP_851353.1

    Status: PROVISIONAL

    Source sequence(s)
    S37093
    UniProtKB/Swiss-Prot
    P17322
    Related
    ENSBTAP00000010649, ENSBTAT00000010649
    Conserved Domains (2) summary
    pfam00322
    Location:4878
    Blast Score: 150
    Endothelin; Endothelin family
    smart00272
    Location:109130
    Blast Score: 96
    END; Endothelin

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

  1. AC_000180.1 Reference Bos_taurus_UMD_3.1 Primary Assembly

    Range
    44010442..44017425, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007324.5 Alternate Btau_4.6.1

    Range
    43785592..43792575, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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