My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    GOLGB1 golgin B1 [ Homo sapiens ]

    Gene ID: 2804, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    GOLGB1provided by HGNC
    Official Full Name
    golgin B1provided by HGNC
    Primary source
    HGNC:4429
    See related
    Ensembl:ENSG00000173230; HPRD:03933; MIM:602500; Vega:OTTHUMG00000159411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP; GCP372; GOLIM1; FLJ37232; DKFZp686F09142
    Help top of page

    Genomic context

    Location :
    3q13
    Sequence :
    Chromosome: 3; NC_000003.11 (121382048..121468602, complement)
    See GOLGB1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene F-box protein 40 Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug. PMID 21697133.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.
    5. Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. Oshikawa M, et al. DNA Res, 2008 Jun 30. PMID 18487259.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data report the characterization of a mammalian coiled-coil protein, CASP, a Golgi protein that shares with giantin a conserved histidine in its transmembrane domain.
      Title: CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.
    2. Giantin binds to Rab6A and Rab1 proteins.
      Title: Giantin interacts with both the small GTPase Rab6 and Rab1.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004478.1 NP_003706.1 USO1    BIND  PubMed Giantin interacts with p115. This interaction was modeled on a demonstrated interaction between rat giantin and p115 from an unspecified species. 
    Q14789 Q9H3P7 ACBD3    HPRD  PubMed  
    Q14789 Q9HCU9 BRMS1    HPRD  PubMed  
    Q14789 P51636 CAV2    HPRD  PubMed  
    Q14789 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q14789 O15239 NDUFA1    HPRD  PubMed  
    Q14789 P35080 PFN2    HPRD  PubMed  
    Q14789 P12757 SKIL    HPRD  PubMed  
    Q14789 P11169 SLC2A3    HPRD  PubMed  
    Q14789 O60763 USO1    HPRD  PubMed  
    Q14789 Q9UEU0 VTI1B    HPRD  PubMed  
    BioGRID:109066 BioGRID:122262 ACBD3    BioGRID  PubMed Far Western; Two-hybrid 
    BioGRID:109066 BioGRID:117379 BRMS1    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:111584 MAPK7    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:111238 PFN2    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:112599 SREBF2    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:263568 Sh3d21    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109066 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:109066 BioGRID:114173 USO1    BioGRID  PubMed Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Golgi organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi stack TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    Golgin subfamily B member 1
    Names
    Golgin subfamily B member 1
    giantin
    macrogolgin
    golgi integral membrane protein 1
    372 kDa Golgi complex-associated protein
    golgin B1, golgi integral membrane protein
    golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256486.1 → NP_001243415.1  Golgin subfamily B member 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA127633, AB371588, AB593126, BP320001
      UniProtKB/TrEMBL
      B2ZZ91
      UniProtKB/TrEMBL
      E7EP74
      UniProtKB/TrEMBL
      F1T0J2
      Conserved Domains (3) summary
      COG1196
      Location:1391 – 1769
      Blast Score: 159
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:718 – 1038
      Blast Score: 176
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09726
      Location:1689 – 1893
      Blast Score: 100
      Macoilin; Transmembrane protein

    2. NM_001256487.1 → NP_001243416.1  Golgin subfamily B member 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA127633, AB593126, BP320001, D25542
      UniProtKB/TrEMBL
      F1T0J2
      UniProtKB/Swiss-Prot
      Q14789
      Conserved Domains (3) summary
      COG1196
      Location:1352 – 1730
      Blast Score: 158
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:679 – 999
      Blast Score: 176
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09726
      Location:1650 – 1854
      Blast Score: 100
      Macoilin; Transmembrane protein

    3. NM_001256488.1 → NP_001243417.1  Golgin subfamily B member 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also lacks an internal in-frame exon and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AA127633, AB593126, BP320001, X75304
      UniProtKB/TrEMBL
      F1T0J2
      UniProtKB/Swiss-Prot
      Q14789
      Conserved Domains (3) summary
      COG1196
      Location:1311 – 1689
      Blast Score: 158
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:638 – 958
      Blast Score: 176
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09726
      Location:1609 – 1813
      Blast Score: 100
      Macoilin; Transmembrane protein

    4. NM_004487.4 → NP_004478.3  Golgin subfamily B member 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA127633, AB593126, BP320001, X75304
      Consensus CDS
      CCDS3004.1
      UniProtKB/TrEMBL
      F1T0J2
      UniProtKB/Swiss-Prot
      Q14789
      Related
      ENSP00000341848, OTTHUMP00000215187, ENST00000340645, OTTHUMT00000355159
      Conserved Domains (3) summary
      COG1196
      Location:1386 – 1764
      Blast Score: 159
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:713 – 1033
      Blast Score: 177
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09726
      Location:1684 – 1888
      Blast Score: 101
      Macoilin; Transmembrane protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      121382048..121468602, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      118756177..118842582, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC119736.7 (2002..35777) None
    genomic AC133750.2 (34608..87385) None
    genomic CH471052.2 EAW79502.1
      EAW79503.1
      EAW79504.1
    mRNA AA127633.1 None
    mRNA AB371588.1 BAG48317.1
    mRNA AB593126.1 BAJ84066.1
    mRNA AK094551.1 None
    mRNA AK296903.1 BAG59460.1
    mRNA AK298986.1 BAG61079.1
    mRNA AK300437.1 BAG62161.1
    mRNA BC065301.1 None
    mRNA BF061034.1 None
    mRNA BM475510.1 None
    mRNA BP320001.1 None
    mRNA BX537520.1 None
    mRNA D25542.1 BAA05025.1
    mRNA X75304.1 CAA53052.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14789.2 GenPept UniProtKB/Swiss-Prot:Q14789
    Q6PG47 GenPept UniProtKB/TrEMBL:Q6PG47
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...