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GNRH2 gonadotropin releasing hormone 2 [ Homo sapiens (human) ]

Gene ID: 2797, updated on 8-May-2016
Official Symbol
GNRH2provided by HGNC
Official Full Name
gonadotropin releasing hormone 2provided by HGNC
Primary source
HGNC:HGNC:4420
See related
Ensembl:ENSG00000125787 HPRD:03830; MIM:602352; Vega:OTTHUMG00000031723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GnRH-II; LH-RHII
Summary
This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Orthologs
Location:
20p13
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (3039061..3045860)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3024268..3026391)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PC-esterase domain containing 1A Neighboring gene VPS16, CORVET/HOPS core subunit Neighboring gene protein tyrosine phosphatase, receptor type A Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene uncharacterized LOC101929098 Neighboring gene oxytocin/neurophysin I prepropeptide

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Hormone ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Hormone ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to hormone ligands are annotated here. The hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and hu...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
Preferred Names
progonadoliberin-2
Names
GnRH-associated peptide 2
GnRH-associated peptide II
Gonadoliberin II
Gonadoliberin-2
gonadotropin-releasing hormone 2
luliberin II
luteinizing hormone-releasing hormone II
progonadoliberin II

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310220.1NP_001297149.1  progonadoliberin-2 isoform a preproprotein

    See identical proteins and their annotated locations for NP_001297149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (a).
    Source sequence(s)
    AF036330, BC115400
    UniProtKB/Swiss-Prot
    O43555
  2. NM_001501.1NP_001492.1  progonadoliberin-2 isoform a preproprotein

    See identical proteins and their annotated locations for NP_001492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 4 encode the same isoform (a).
    Source sequence(s)
    AF036330, BC069362
    Consensus CDS
    CCDS13040.1
    UniProtKB/Swiss-Prot
    O43555
    Related
    ENSP00000245983, OTTHUMP00000030075, ENST00000245983, OTTHUMT00000077694
  3. NM_178331.1NP_847901.1  progonadoliberin-2 isoform c preproprotein

    See identical proteins and their annotated locations for NP_847901.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AF036330, BC115399
    Consensus CDS
    CCDS13041.1
    UniProtKB/Swiss-Prot
    O43555
    Related
    ENSP00000352003, OTTHUMP00000030078, ENST00000359100, OTTHUMT00000077697
  4. NM_178332.1NP_847902.1  progonadoliberin-2 isoform b preproprotein

    See identical proteins and their annotated locations for NP_847902.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AF036330, BF061974
    Consensus CDS
    CCDS13042.1
    UniProtKB/Swiss-Prot
    O43555
    Related
    ENSP00000369704, OTTHUMP00000030076, ENST00000380346, OTTHUMT00000077695

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    3039061..3045860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529220.1XP_011527522.1  

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    3019097..3021220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)