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Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [ Mus musculus (house mouse) ]

Gene ID: 27756, updated on 28-May-2016
Official Symbol
Lsm2provided by MGI
Official Full Name
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by MGI
Primary source
MGI:MGI:90676
See related
Ensembl:ENSMUSG00000007050 Vega:OTTMUSG00000037141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G7b; SmX5; Dmapl; Sm-X5; snRNP; Dmpkap; D17H6S56E2; D17H6S56E-2
Orthologs
Location:
17 B1; 17 18.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (34981854..34985891)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35118805..35122836)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene heat shock protein 1A Neighboring gene heat shock protein 1-like Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene valyl-tRNA synthetase

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC13889

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Ral GTPase binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic mRNA processing body IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
U6 snRNA-associated Sm-like protein LSm2
Names
G7b alternative form
LSM2 homolog, U6 small nuclear RNA associated
dystrophia myotonica-protein kinase associated protein
small ribonuclear protein G7b
snRNP core Sm-like protein Sm-x5
snRNP core protein SMX5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110101.2NP_001103571.1  U6 snRNA-associated Sm-like protein LSm2 isoform 2

    See identical proteins and their annotated locations for NP_001103571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and uses an upstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compare to variant 1.
    Source sequence(s)
    AC087117, AF204150, AK151605
    Consensus CDS
    CCDS50081.1
    UniProtKB/Swiss-Prot
    O35900
    UniProtKB/TrEMBL
    O35901, Q3U9X2
    Related
    ENSMUSP00000109644, OTTMUSP00000053366, ENSMUST00000114011, OTTMUST00000095633
    Conserved Domains (1) summary
    cd01725
    Location:290
    LSm2; Like-Sm protein 2
  2. NM_001204273.1NP_001191202.1  U6 snRNA-associated Sm-like protein LSm2 isoform 3

    See identical proteins and their annotated locations for NP_001191202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087117
    Consensus CDS
    CCDS57069.1
    UniProtKB/TrEMBL
    G3UZ96
    Related
    ENSMUSP00000134403, OTTMUSP00000053368, ENSMUST00000173004, OTTMUST00000095639
    Conserved Domains (1) summary
    cl00259
    Location:3859
    Sm_like; Sm and related proteins
  3. NM_001204274.1NP_001191203.1  U6 snRNA-associated Sm-like protein LSm2 isoform 4

    See identical proteins and their annotated locations for NP_001191203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087117
    Conserved Domains (1) summary
    cd01725
    Location:253
    LSm2; Like-Sm protein 2
  4. NM_030597.3NP_085100.1  U6 snRNA-associated Sm-like protein LSm2 isoform 1

    See identical proteins and their annotated locations for NP_085100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF204150, BB848823
    Consensus CDS
    CCDS28671.1
    UniProtKB/TrEMBL
    O35901
    Related
    ENSMUSP00000007266, OTTMUSP00000053367, ENSMUST00000007266, OTTMUST00000095636
    Conserved Domains (1) summary
    cd01725
    Location:38126
    LSm2; Like-Sm protein 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    34981854..34985891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p3 129X1/SvJ

    Range
    1231548..1235585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    1300758..1304792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    1300997..1305031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    38078080..38082117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)