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Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

Gene ID: 276770, updated on 8-May-2016
Official Symbol
Eif5aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 5Aprovided by MGI
Primary source
MGI:MGI:106248
See related
Ensembl:ENSMUSG00000078812 Vega:OTTMUSG00000006023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; AA410058; eIF-5A-1; D19Wsu54e
Summary
This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Orthologs
Location:
11; 11 B3
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (69916712..69921958, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69730214..69735460, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC6725

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding ISO
Inferred from Sequence Orthology
more info
 
U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
translational frameshifting IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
eukaryotic translation initiation factor 5A-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166589.1NP_001160061.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000047008, OTTMUSP00000006259, ENSMUST00000043419, OTTMUST00000013511
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  2. NM_001166590.1NP_001160062.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000104250, OTTMUSP00000006264, ENSMUST00000108610, OTTMUST00000013516
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  3. NM_001166591.1NP_001160063.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000067077, OTTMUSP00000016809, ENSMUST00000070996, OTTMUST00000037511
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  4. NM_001166592.1NP_001160064.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000104251, OTTMUSP00000006263, ENSMUST00000108611, OTTMUST00000013515
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  5. NM_001166593.1NP_001160065.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000068651, OTTMUSP00000016810, ENSMUST00000071026, OTTMUST00000037512
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  6. NM_001166594.1NP_001160066.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000104252, OTTMUSP00000006262, ENSMUST00000108612, OTTMUST00000013514
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  7. NM_001166595.1NP_001160067.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  8. NM_001166596.1NP_001160068.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000132717, ENSMUST00000164359
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  9. NM_181582.4NP_853613.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_853613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000104253, OTTMUSP00000006258, ENSMUST00000108613, OTTMUST00000013510
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    69916712..69921958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249058.1XP_011247360.1  

    See identical proteins and their annotated locations for XP_011247360.1

    UniProtKB/Swiss-Prot
    P63242
    Related
    ENSMUSP00000104249, OTTMUSP00000006261, ENSMUST00000108609, OTTMUST00000013513
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187026.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    21240..26486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011251270.1XP_011249572.1  

    See identical proteins and their annotated locations for XP_011249572.1

    UniProtKB/Swiss-Prot
    P63242
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    77464600..77469965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)