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Amot angiomotin [ Mus musculus (house mouse) ]

Gene ID: 27494, updated on 28-May-2016
Official Symbol
Amotprovided by MGI
Official Full Name
angiomotinprovided by MGI
Primary source
MGI:MGI:108440
See related
Ensembl:ENSMUSG00000041688 Vega:OTTMUSG00000018901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sii6; CAG-2; D0Kist1
Orthologs
Location:
X; X F2
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (145446424..145505541, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (141880967..141921589, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene lipoma HMGIC fusion partner-like 1 Neighboring gene prefoldin 5 pseudogene Neighboring gene predicted gene 6446

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • mKIAA1071, E230009N18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
angiostatin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity involved in ameboidal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
stress fiber ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290274.1NP_001277203.1  angiomotin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and it's 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL807753
    UniProtKB/Swiss-Prot
    Q8VHG2
    Conserved Domains (3) summary
    pfam07223
    Location:191457
    DUF1421; Protein of unknown function (DUF1421)
    pfam12240
    Location:578787
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:436617
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_153319.3NP_695231.3  angiomotin isoform 1

    See identical proteins and their annotated locations for NP_695231.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI854771, AK129277, AL807753
    Consensus CDS
    CCDS72443.1
    UniProtKB/Swiss-Prot
    Q8VHG2
    Related
    ENSMUSP00000108455, ENSMUST00000112836
    Conserved Domains (3) summary
    pfam12240
    Location:578787
    Angiomotin_C; Angiomotin C terminal
    pfam15619
    Location:482650
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl12013
    Location:436617
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    145446424..145505541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247828.1XP_011246130.1  

    See identical proteins and their annotated locations for XP_011246130.1

    UniProtKB/Swiss-Prot
    Q8VHG2
    Conserved Domains (3) summary
    pfam12240
    Location:578787
    Angiomotin_C; Angiomotin C terminal
    pfam15619
    Location:482650
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl12013
    Location:436617
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_006528864.2XP_006528927.1  

    See identical proteins and their annotated locations for XP_006528927.1

    UniProtKB/Swiss-Prot
    Q8VHG2
    Conserved Domains (3) summary
    pfam12240
    Location:578787
    Angiomotin_C; Angiomotin C terminal
    pfam15619
    Location:482650
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl12013
    Location:436617
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_006528867.2XP_006528930.1  

    Related
    ENSMUSP00000108454, OTTMUSP00000020435, ENSMUST00000112835, OTTMUST00000045442
    Conserved Domains (2) summary
    pfam12240
    Location:289498
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:147328
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    129393202..129434374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)