Format

Send to:

Choose Destination

GLUD2 glutamate dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 2747, updated on 8-May-2016
Official Symbol
GLUD2provided by HGNC
Official Full Name
glutamate dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:4336
See related
Ensembl:ENSG00000182890 HPRD:02143; MIM:300144; Vega:OTTHUMG00000022320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDH2; GLUDP1
Summary
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Orthologs
Location:
Xq24-q25
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (121047608..121049942)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (120181462..120183796)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 47, member A1 Neighboring gene uncharacterized LOC105373328 Neighboring gene Cbl proto-oncogene like 1 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 1 Neighboring gene microRNA 3672

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of glutamate dehydrogenase 2 (GLUD2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Alanine, aspartate and glutamate metabolism, organism-specific biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, organism-specific biosystem
    Alanine, aspartate and glutamate metabolism
  • Alanine, aspartate and glutamate metabolism, conserved biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, conserved biosystem
    Alanine, aspartate and glutamate metabolism
  • Amino acid synthesis and interconversion (transamination), organism-specific biosystem (from REACTOME)
    Amino acid synthesis and interconversion (transamination), organism-specific biosystemThese reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four am...
  • Arginine biosynthesis, organism-specific biosystem (from KEGG)
    Arginine biosynthesis, organism-specific biosystem
    Arginine biosynthesis
  • Arginine biosynthesis, conserved biosystem (from KEGG)
    Arginine biosynthesis, conserved biosystem
    Arginine biosynthesis
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • D-Glutamine and D-glutamate metabolism, organism-specific biosystem (from KEGG)
    D-Glutamine and D-glutamate metabolism, organism-specific biosystem
    D-Glutamine and D-glutamate metabolism
  • D-Glutamine and D-glutamate metabolism, conserved biosystem (from KEGG)
    D-Glutamine and D-glutamate metabolism, conserved biosystem
    D-Glutamine and D-glutamate metabolism
  • GABA shunt, organism-specific biosystem (from BIOCYC)
    GABA shunt, organism-specific biosystemBackground : 4-AMINO-BUTYRATE "GABA" and : GLT are the most abundant neurotransmitters in mammalian brain. While : 4-AMINO-BUTYRATE "GABA" is the major inhibitory neurotransmitter, : GLT is an excit...
  • GABA shunt, conserved biosystem (from BIOCYC)
    GABA shunt, conserved biosystemBackground |FRAME: 4-AMINO-BUTYRATE "GABA"| and |FRAME: GLT| are the most abundant neurotransmitters in mammalian brain. While |FRAME: 4-AMINO-BUTYRATE "GABA"| is the major inhibitory neurotransmitt...
  • L-glutamate and L-glutamine biosynthesis, conserved biosystem (from BIOCYC)
    L-glutamate and L-glutamine biosynthesis, conserved biosystemPlease note: This collection of reactions does not represent the metabolism of a single organism. Rather, it is assembled from a variety of organisms. Its purpose is to provide an overview of the wa...
  • L-glutamate biosynthesis II, conserved biosystem (from BIOCYC)
    L-glutamate biosynthesis II, conserved biosystemGlutamate is biosynthesized in the mitochondrion from the tricarboxylic acid (TCA) cycle intermediate alpha-ketoglutarate. As shown in this pathway, glutamate dehydrogenase NAD(P)+ produces glutamat...
  • L-glutamate degradation X, conserved biosystem (from BIOCYC)
    L-glutamate degradation X, conserved biosystemIn this pathway |FRAME:GLT| is deaminated by an NAD(P)-dependent dehydrogenase, forming |FRAME:AMMONIA| and |FRAME:2-KETOGLUTARATE|, which is then fed to the |FRAME:TCA|. The deamination of |FRAME: G...
  • L-ornithine biosynthesis II, conserved biosystem (from BIOCYC)
    L-ornithine biosynthesis II, conserved biosystemGeneral Background |FRAME: L-ORNITHINE| is an amino acid, but it is not a component of proteins nor is it coded for by DNA. In mammals, it plays a role in the |FRAME: PWY-4984| for the disposal of a...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Nitrogen metabolism, organism-specific biosystem (from KEGG)
    Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Nitrogen metabolism, conserved biosystem (from KEGG)
    Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • glutamate biosynthesis/degradation, organism-specific biosystem (from BIOCYC)
    glutamate biosynthesis/degradation, organism-specific biosystemGeneral Background : GLT is a non-essential amino acid. It plays an essential role in the central nervous system as an excitatory neurotransmitter involved in long term potentiation which is vital f...
  • ornithine de novo biosynthesis, organism-specific biosystem (from BIOCYC)
    ornithine de novo biosynthesis, organism-specific biosystemGeneral Background : L-ORNITHINE is an amino acid, but it is not a component of proteins nor is it coded for by DNA. In mammals, it plays a role in the : PWY-4984 for the disposal of ammonia where i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
glutamate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
glutamate dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
PubMed 
leucine binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
glutamate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glutamate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glutamate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glutamate dehydrogenase 2, mitochondrial
Names
GDH 2
glutamate dehydrogenase pseudogene 1
testicular secretory protein Li 14
NP_036216.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016456.1 RefSeqGene

    Range
    5001..7335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012084.3NP_036216.2  glutamate dehydrogenase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036216.2

    Status: REVIEWED

    Source sequence(s)
    BC050732
    Consensus CDS
    CCDS14603.1
    UniProtKB/Swiss-Prot
    P49448
    Related
    ENSP00000327589, OTTHUMP00000023966, ENST00000328078, OTTHUMT00000058133
    Conserved Domains (3) summary
    cd01076
    Location:263548
    NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
    COG0334
    Location:104555
    GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
    pfam02812
    Location:112240
    ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    121047608..121049942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    120092469..120094803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)