These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_012163.1 RefSeqGene
- Range
- 5001..9152
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_013247.4 → NP_037379.1 serine protease HTRA2, mitochondrial isoform 1 preproprotein
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1).
- Source sequence(s)
-
AF141305, BF939362
- Consensus CDS
-
CCDS1951.1
- UniProtKB/Swiss-Prot
-
O43464
- Related
- ENSP00000258080, OTTHUMP00000160415, ENST00000258080, OTTHUMT00000252219
- Conserved Domains (2) summary
-
- cd00987
Location:360 – 452
Blast Score: 171
- PDZ_serine_protease; PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
- cl00149
Location:182 – 320
Blast Score: 216
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
-
NM_145074.2 → NP_659540.1 serine protease HTRA2, mitochondrial isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1 and has a modified PDZ domain. Isoform 2 has no detectable protease activity.
- Source sequence(s)
-
AF141305, AF184911, BF939362
- Consensus CDS
-
CCDS1952.1
- UniProtKB/Swiss-Prot
-
O43464
- Related
- ENSP00000312893, OTTHUMP00000160416, ENST00000352222, OTTHUMT00000252220
- Conserved Domains (2) summary
-
- cd00989
Location:307 – 357
Blast Score: 113
- PDZ_metalloprotease; PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ ...
- cl00149
Location:182 – 296
Blast Score: 116
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000002.11 Reference GRCh37.p5 Primary Assembly
- Range
- 74756532..74760683
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000134.1 Alternate HuRef
- Range
- 74492793..74496944
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)