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GLRA2 glycine receptor alpha 2 [ Homo sapiens (human) ]

Gene ID: 2742, updated on 8-May-2016
Official Symbol
GLRA2provided by HGNC
Official Full Name
glycine receptor alpha 2provided by HGNC
Primary source
HGNC:HGNC:4327
See related
Ensembl:ENSG00000101958 HPRD:02379; MIM:305990; Vega:OTTHUMG00000021166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLR
Summary
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Orthologs
Location:
Xp22.2
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (14448779..14731812)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (14547420..14749934)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 8 Neighboring gene ubiquitin conjugating enzyme E2 E4 pseudogene Neighboring gene Fanconi anemia complementation group B Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 9 Neighboring gene motile sperm domain containing 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular-glycine-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
glycine-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission, postsynaptic IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glycinergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
glycine receptor subunit alpha-2
Names
glycine receptor alpha 2 subunit
glycine receptor, alpha 2
glycine receptor, alpha-2 polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016459.1 RefSeqGene

    Range
    5001..207515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118885.1NP_001112357.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_001112357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (A).
    Source sequence(s)
    AA081959, AK312591, BC045547
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (3) summary
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
  2. NM_001118886.1NP_001112358.1  glycine receptor subunit alpha-2 isoform B precursor

    See identical proteins and their annotated locations for NP_001112358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks an exon, compared to variant 1, resulting in a protein (isoform B) of identical length but differing in 2 amino acids, compared to isoform A.
    Source sequence(s)
    AA081959, AK289561, AK312591, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS48085.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000347123, OTTHUMP00000225926, ENST00000355020, OTTHUMT00000055831
    Conserved Domains (3) summary
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
  3. NM_001171942.1NP_001165413.1  glycine receptor subunit alpha-2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A.
    Source sequence(s)
    AC003658, AK297304, AK312591, BC045547
    Consensus CDS
    CCDS55371.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000387756, ENST00000443437
    Conserved Domains (2) summary
    pfam02931
    Location:1165
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:172349
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  4. NM_002063.3NP_002054.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_002054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform A.
    Source sequence(s)
    AA081959, AK312591, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000218075, OTTHUMP00000022950, ENST00000218075, OTTHUMT00000055829
    Conserved Domains (3) summary
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    14448779..14731812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545495.1XP_011543797.1  

    See identical proteins and their annotated locations for XP_011543797.1

    Conserved Domains (3) summary
    pfam02931
    Location:32238
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:245422
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
  2. XM_011545496.1XP_011543798.1  

    See identical proteins and their annotated locations for XP_011543798.1

    Conserved Domains (3) summary
    pfam02931
    Location:32238
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:245422
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
  3. XM_006724487.2XP_006724550.1  

    See identical proteins and their annotated locations for XP_006724550.1

    Conserved Domains (3) summary
    pfam02931
    Location:32238
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:245422
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    14577845..14780315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)