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Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 [ Mus musculus (house mouse) ]

Gene ID: 27409, updated on 8-May-2016
Official Symbol
Abcg5provided by MGI
Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 5provided by MGI
Primary source
MGI:MGI:1351659
See related
Ensembl:ENSMUSG00000040505 Vega:OTTMUSG00000036704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cmp; trac; sterolin-1
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily, and functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. Disruption of this gene in mice results in thrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, shortened life span and cardiomyopathy. Mice lacking this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov 2015]
Orthologs
Location:
17 E4; 17 55.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (84658234..84682923, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (85057574..85082263, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 8 Neighboring gene leucine-rich PPR-motif containing Neighboring gene post-GPI attachment to proteins 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Clone Names

  • MGC123400

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to cholesterol transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to cholesterol transporter activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
excretion ISO
Inferred from Sequence Orthology
more info
 
intestinal cholesterol absorption IC
Inferred by Curator
more info
PubMed 
negative regulation of intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intestinal phytosterol absorption ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATP-binding cassette (ABC) transporter complex ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-binding cassette sub-family G member 5
Names
sterolin 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031884.2NP_114090.1  ATP-binding cassette sub-family G member 5

    See identical proteins and their annotated locations for NP_114090.1

    Status: REVIEWED

    Source sequence(s)
    AF312713, BB798401
    Consensus CDS
    CCDS29001.1
    UniProtKB/Swiss-Prot
    Q99PE8
    UniProtKB/TrEMBL
    Q540E8
    Related
    ENSMUSP00000069495, OTTMUSP00000052239, ENSMUST00000066175, OTTMUST00000094038
    Conserved Domains (3) summary
    cd03234
    Location:50276
    ABCG_White; White pigment protein homolog of ABCG transporter subfamily
    pfam01061
    Location:369581
    ABC2_membrane; ABC-2 type transporter
    TIGR00955
    Location:61646
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    84658234..84682923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    89024999..89050375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)