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Msrb1 methionine sulfoxide reductase B1 [ Mus musculus (house mouse) ]

Gene ID: 27361, updated on 8-May-2016
Official Symbol
Msrb1provided by MGI
Official Full Name
methionine sulfoxide reductase B1provided by MGI
Primary source
MGI:MGI:1351642
See related
Ensembl:ENSMUSG00000075705 Vega:OTTMUSG00000021061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SELX; SelR; Sepr; Sepx1; D17Wsu82e
Summary
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and is localized in the cytosol and nucleus. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17 A3.3; 17 12.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (24736642..24742778)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24873587..24879723)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 Neighboring gene ribosomal protein L3-like Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Neighboring gene meiosis specific with OB domains

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methionine-R-sulfoxide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
 
peptide-methionine (R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
protein repair IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
methionine-R-sulfoxide reductase B1
Names
selenoprotein R
selenoprotein X 1
NP_038787.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013759.2NP_038787.1  methionine-R-sulfoxide reductase B1

    See identical proteins and their annotated locations for NP_038787.1

    Status: REVIEWED

    Source sequence(s)
    AF195142, AK002652, CX566836
    Consensus CDS
    CCDS28495.1
    UniProtKB/Swiss-Prot
    Q9JLC3
    Related
    ENSMUSP00000110917, OTTMUSP00000023144, ENSMUST00000115262, OTTMUST00000049818
    Conserved Domains (1) summary
    cl15841
    Location:7108
    SelR; SelR domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    24736642..24742778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    25259999..25266140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)