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    GLG1 golgi glycoprotein 1 [ Homo sapiens ]

    Gene ID: 2734, updated on 11-May-2012
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    Summary

    Official Symbol
    GLG1provided by HGNC
    Official Full Name
    golgi glycoprotein 1provided by HGNC
    Primary source
    HGNC:4316
    See related
    Ensembl:ENSG00000090863; HPRD:02855; MIM:600753; Vega:OTTHUMG00000177174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFR-1; ESL-1; MG160; MG-160; FLJ23319; FLJ23967; FLJ32797; DKFZp686L08213
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    Genomic context

    Location :
    16q22.3
    Sequence :
    Chromosome: 16; NC_000016.9 (74481325..74641042, complement)
    See GLG1 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene nuclear pore complex interacting protein-like 2 Neighboring gene C-type lectin domain family 18, member B Neighboring gene ribosomal protein S10 pseudogene 23 Neighboring gene heat shock 10kDa protein 1 (chaperonin 10) pseudogene Neighboring gene ring finger and WD repeat domain 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Zarbock A, et al. Blood, 2011 Dec 22. PMID 22021370.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms. Miyaoka Y, et al. Biochem J, 2011 Nov 15. PMID 21777203.
    4. C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells. St Hill CA, et al. PLoS One, 2011 Jan 19. PMID 21283832.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin.
      Title: Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
    2. expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions.
      Title: Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms.
    3. C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential.
      Title: C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
    5. Genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A pilot genome-wide association study of early-onset breast cancer.
    6. under hypoxia, ESL-1 is shed from activated hepatic stellate cells
      Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
    7. evaluated in human brain tumors exhibiting varying degrees of malignancy
      Title: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas.
    8. a novel variant of the GLG1 gene product called GLG2 is reported; genetic analysis suggests GLG1 & GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate different transcripts encoding GLG1 or GLG2
      Title: A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A pilot genome-wide association study of early-onset breast cancer.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q92896 Q00653 NFKB2    HPRD  PubMed  
    Q92896 P16581 SELE    HPRD  PubMed  
    BioGRID:108996 BioGRID:110858 NFKB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108996 BioGRID:112301 SELE    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108996 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108996 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fibroblast growth factor 2 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi medial cisterna IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    microsome IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    Golgi apparatus protein 1
    Names
    Golgi apparatus protein 1
    E-selectin ligand 1
    golgi sialoglycoprotein MG-160
    cysteine-rich fibroblast growth factor receptor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145666.1 → NP_001139138.1  Golgi apparatus protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC009053, AK304156, BC060822, BX648396, DA493962
      Consensus CDS
      CCDS45526.1
      UniProtKB/Swiss-Prot
      Q92896
      Related
      ENSP00000406946, OTTHUMP00000256061, ENST00000447066, OTTHUMT00000435751
      Conserved Domains (1) summary
      pfam00839
      Location:789 – 845
      Blast Score: 167
      Cys_rich_FGFR; Cysteine rich repeat

    2. NM_001145667.1 → NP_001139139.1  Golgi apparatus protein 1 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (3) is shorter at the C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC009053, BC060822, BX648396, DA493962, U64791
      Consensus CDS
      CCDS45527.1
      UniProtKB/Swiss-Prot
      Q92896
      Related
      ENSP00000405984, OTTHUMP00000256060, ENST00000422840, OTTHUMT00000435750
      Conserved Domains (1) summary
      pfam00839
      Location:800 – 856
      Blast Score: 166
      Cys_rich_FGFR; Cysteine rich repeat

    3. NM_012201.5 → NP_036333.2  Golgi apparatus protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC009053, AK304156, BC060822, BX648396, DA493962
      Consensus CDS
      CCDS32485.1
      UniProtKB/Swiss-Prot
      Q92896
      Related
      ENSP00000205061, OTTHUMP00000256036, ENST00000205061, OTTHUMT00000435732
      Conserved Domains (1) summary
      pfam00839
      Location:800 – 856
      Blast Score: 167
      Cys_rich_FGFR; Cysteine rich repeat

    RNA

    1. NR_027264.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) has an additional exon in the middle region and an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      AC009053, AK027032, AK304156, BX648396, DA493962

    2. NR_027265.1 RNA Sequence

      Description
      Transcript Variant: This variant (5) lacks several internal exons and has an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      AC009053, BC031836, BC060822, BX648396, DA493962

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      74481325..74641042, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      60230839..60390962, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009053.7 None
    genomic AC009153.10 None
    genomic AC109599.4 (93285..147115) None
    genomic CH471114.2 EAW95682.1
      EAW95683.1
      EAW95684.1
      EAW95685.1
      EAW95686.1
    genomic HC309812.1 CBJ21213.1
    mRNA AK025457.1 None
    mRNA AK026972.1 None
    mRNA AK027032.1 None
    mRNA AK057359.1 None
    mRNA AK095842.1 None
    mRNA AK131501.1 None
    mRNA AK172806.1 BAD18777.1
    mRNA AK304156.1 BAH14120.1
    mRNA BC031836.1 None
    mRNA BC040133.1 None
    mRNA BC060822.1 AAH60822.1
    mRNA BG719482.1 None
    mRNA BI561038.1 None
    mRNA BX648396.1 None
    mRNA DA493962.1 None
    mRNA U28811.1 AAB02178.1
    mRNA U64791.1 AAB06460.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMF1 GenPept UniProtKB/TrEMBL:Q6ZMF1
    Q92896.2 GenPept UniProtKB/Swiss-Prot:Q92896
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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