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    DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 27292, updated on 11-May-2012
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    Summary

    Official Symbol
    DIMT1provided by HGNC
    Official Full Name
    DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:30217
    Locus tag
    HUSSY-05
    See related
    Ensembl:ENSG00000086189; HPRD:13676; MIM:612499; Vega:OTTHUMG00000131223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIM1; DIMT1L; HUSSY5; HSA9761
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    Genomic context

    Location :
    5q12.1
    Sequence :
    Chromosome: 5; NC_000005.9 (61684351..61699728, complement)
    See DIMT1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene actin, beta pseudogene Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin heavy chain member 2A Neighboring gene importin 11 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene ribosomal protein L35a pseudogene 14

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UNQ2 Q14511 NEDD9    HPRD  PubMed  
    BioGRID:118116 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118116 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118116 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118116 BioGRID:123904 USP42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118116 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the DIMT1 gene: The DIMT1 gene is conserved in chimpanzee, , cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    probable dimethyladenosine transferase
    Names
    probable dimethyladenosine transferase
    18S rRNA dimethylase
    dimethyladenosine transferase
    probable 18S rRNA dimethylase
    S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    NP_055288.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014473.2 → NP_055288.1  probable dimethyladenosine transferase

      Status: VALIDATED

      Source sequence(s)
      AF091078, AF102147, BC010874, BC017885, BM749030
      Consensus CDS
      CCDS3981.1
      UniProtKB/Swiss-Prot
      Q9UNQ2
      Related
      ENSP00000199320, OTTHUMP00000161884, ENST00000199320, OTTHUMT00000253967
      Conserved Domains (1) summary
      cl16911
      Location:24 – 312
      Blast Score: 1176
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      61684351..61699728, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      58640805..58656022, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016637.7 (60534..75911) None
    genomic CH471137.2 EAW51384.1
      EAW51385.1
      EAW51386.1
    mRNA AF091078.1 AAC72947.1
    mRNA AF102147.1 AAC97955.1
    mRNA AJ009761.1 CAA08815.1
    mRNA AK292723.1 BAF85412.1
    mRNA AK299480.1 BAG61444.1
    mRNA BC002841.2 AAH02841.1
    mRNA BC010874.2 AAH10874.1
    mRNA BC017885.1 None
    mRNA BM749030.1 None
    other-genetic DQ891482.2 ABM82408.1
    other-genetic DQ894669.2 ABM85595.1
    other-genetic DQ894841.2 ABM85767.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNQ2.1 GenPept UniProtKB/Swiss-Prot:Q9UNQ2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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