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DIMT1 DIM1 dimethyladenosine transferase 1 homolog [ Homo sapiens (human) ]

Gene ID: 27292, updated on 8-May-2016
Official Symbol
DIMT1provided by HGNC
Official Full Name
DIM1 dimethyladenosine transferase 1 homologprovided by HGNC
Primary source
HGNC:HGNC:30217
See related
Ensembl:ENSG00000086189 HPRD:13676; MIM:612499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIM1; DIMT1L; HUSSY5; HSA9761
Orthologs
Location:
5q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (62388524..62403901, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61684351..61699728, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378998 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin heavy chain member 2A Neighboring gene importin 11 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene ribosomal protein L35a pseudogene 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of DIM1 dimethyladenosine transferase 1 homolog (DIMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • rRNA modification in the nucleus, organism-specific biosystem (from REACTOME)
    rRNA modification in the nucleus, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
rRNA (adenine-N6,N6-)-dimethyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
rRNA methylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
probable dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
18S rRNA dimethylase
S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
dimethyladenosine transferase
probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
probable 18S rRNA dimethylase
probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
NP_055288.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014473.2NP_055288.1  probable dimethyladenosine transferase

    See identical proteins and their annotated locations for NP_055288.1

    Status: VALIDATED

    Source sequence(s)
    AF091078, AF102147, BC010874, BC017885, BM749030
    Consensus CDS
    CCDS3981.1
    UniProtKB/Swiss-Prot
    Q9UNQ2
    Related
    ENSP00000199320, OTTHUMP00000161884, ENST00000199320, OTTHUMT00000253967
    Conserved Domains (1) summary
    cd02440
    Location:60160
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    62388524..62403901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543323.1XP_011541625.1  

    Conserved Domains (1) summary
    cl17173
    Location:1159
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    61684014..61699390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)