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    LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 27257, updated on 5-Feb-2012

    Summary

    Official Symbol
    LSM1provided by HGNC
    Official Full Name
    LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:20472
    See related
    Ensembl:ENSG00000175324; HPRD:06281; MIM:607281; Vega:OTTHUMG00000164051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CASM; YJL124C
    Summary
    This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

    Genomic context

    Location :
    8p11.2
    Sequence :
    Chromosome: 8; NC_000008.10 (38020857..38034026, complement)
    See LSM1 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene ash2 (absent, small, or homeotic)-like (Drosophila) Neighboring gene steroidogenic acute regulatory protein Neighboring gene BCL2-associated athanogene 4 Neighboring gene DDHD domain containing 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O15116 O00299 CLIC1    HPRD  PubMed  
    O15116 Exosome component 6 EXOSC6    HPRD  PubMed  
    O15116 Q96B26 EXOSC8    HPRD  PubMed  
    O15116 Q9UBQ7 GRHPR    HPRD  PubMed  
    O15116 P07900 HSP90AA1    HPRD  PubMed  
    O15116 Q9Y333 LSM2    HPRD  PubMed  
    O15116 P62310 LSM3    HPRD  PubMed  
    O15116 Q9Y4Y9 LSM5    HPRD  PubMed  
    O15116 P62312 LSM6    HPRD  PubMed  
    O15116 Q9UK45 LSM7    HPRD  PubMed  
    O15116 O43776 NARS    HPRD  PubMed  
    O15116 Q9BU61 NDUFAF3    HPRD  PubMed  
    O15116 P28074 PSMB5    HPRD  PubMed  
    O15116 P28062 PSMB8    HPRD  PubMed  
    O15116 P08575 PTPRC    HPRD  PubMed  
    O15116 Q14684 RRP1B    HPRD  PubMed  
    O15116 Q16637 SMN2    HPRD  PubMed  
    O15116 Hypothetical protein FLJ20254 TMEM214    HPRD  PubMed  
    O15116 Q9HAU5 UPF2    HPRD  PubMed  
    O15116 Q9UBK9 UXT    HPRD  PubMed  
    O15116 Q9H270 VPS11    HPRD  PubMed  
    BioGRID:118104 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118104 BioGRID:107604 CLIC1    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:125608 EXOSC6    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:116468 EXOSC8    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:114781 GRHPR    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:109552 HSP90AA1    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:121778 LSM2    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:117336 LSM4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118104 BioGRID:115036 N4BP1    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:110758 NARS    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:117419 NDUFAF3    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:111666 PSMB5    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:111669 PSMB8    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:120216 TMEM214    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:117490 UPF2    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:113997 UXT    BioGRID  PubMed Two-hybrid 
    BioGRID:118104 BioGRID:120930 VPS11    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    • Homologs of the LSM1 gene: The LSM1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, and A.thaliana.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The "expression" of non-protein-coding genes is ...
    • Lsm 1-7 complex, organism-specific biosystem (from KEGG)
      Lsm 1-7 complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • mRNA Decay by 5' to 3' Exoribonuclease, organism-specific biosystem (from REACTOME)
      mRNA Decay by 5' to 3' Exoribonuclease, organism-specific biosystemDegradation of mRNA from 5' to 3' occurs in three steps. First, the mRNA is bound at its 3' end by the Lsm1-7 complex. The bound Lsm1-7 may prevent nucleases from accessing the 3' end. Second, the 7-...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA splicing, via transesterification reactions TAS
    Traceable Author Statement
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
    Traceable Author Statement
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    U6 snRNA-associated Sm-like protein LSm1
    Names
    U6 snRNA-associated Sm-like protein LSm1
    small nuclear ribonuclear CaSm
    cancer-associated Sm-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014462.2NP_055277.1  U6 snRNA-associated Sm-like protein LSm1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and is protein-coding.
      Source sequence(s)
      AJ238094, BE670269, BP376421, BU941962
      Consensus CDS
      CCDS6103.1
      UniProtKB/Swiss-Prot
      O15116
      Related
      ENSP00000310596, OTTHUMP00000225703, ENST00000311351, OTTHUMT00000376965
      Conserved Domains (2) summary
      cd01728
      Location:477
      Blast Score: 334
      LSm1; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of ...
      PRK10788
      Location:82131
      Blast Score: 89
      PRK10788; periplasmic folding chaperone; Provisional

    RNA

    1. NR_045492.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      BE670269, BP376421, BU521199, BU941962
    2. NR_045493.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.
      Source sequence(s)
      AF147348, BE670269, BU941962

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      38020857..38034026, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      36555774..36568414, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC084024.17 (48994..62163) None
    genomic CH471080.2 EAW63332.1
      EAW63333.1
    genomic HC879396.1 CBM42914.1
    genomic HD033105.1 CBV35647.1
    mRNA AF000177.1 AAB62189.1
    mRNA AF147348.1 None
    mRNA AJ238094.1 CAB45865.1
    mRNA AK312159.1 BAG35093.1
    mRNA BC001767.1 AAH01767.1
    mRNA BE670269.1 None
    mRNA BP376421.1 None
    mRNA BU941962.1 None
    Protein Accession Links
    GenePept Link UniProtKB Link
    O15116.1 GenPept UniProtKB/Swiss-Prot:O15116

      Supplemental Content

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