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PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) [ Homo sapiens (human) ]

Gene ID: 27250, updated on 14-Apr-2014
Official Symbol
PDCD4provided by HGNC
Official Full Name
programmed cell death 4 (neoplastic transformation inhibitor)provided by HGNC
Primary source
HGNC:8763
Locus tag
RP11-348N5.4
See related
Ensembl:ENSG00000150593; HPRD:10549; MIM:608610; Vega:OTTHUMG00000019048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H731
Summary
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Location :
10q24
Sequence :
Chromosome: 10; NC_000010.11 (110871795..110900006)
See PDCD4 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724471 Neighboring gene RNA binding motif protein 20 Neighboring gene PDCD4 antisense RNA 1 Neighboring gene microRNA 4680 Neighboring gene BBSome interacting protein 1 Neighboring gene soc-2 suppressor of clear homolog (C. elegans) Neighboring gene ribosomal protein L13a pseudogene 6 Neighboring gene microRNA 548e

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell aging IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
programmed cell death protein 4
Names
programmed cell death protein 4
protein 197/15a
nuclear antigen H731
neoplastic transformation inhibitor protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199492.1NP_001186421.1  programmed cell death protein 4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK296753, AL136368, AL158163, BX647834, DB241608
    UniProtKB/TrEMBL
    B4DKX4
    Conserved Domains (1) summary
    smart00544
    Location:313426
    Blast Score: 325
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  2. NM_014456.4NP_055271.2  programmed cell death protein 4 isoform 1

    See proteins identical to NP_055271.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL136368, AL158163, BC026104, BX647834, DB241608
    Consensus CDS
    CCDS7567.1
    UniProtKB/Swiss-Prot
    Q53EL6
    Related
    ENSP00000280154, OTTHUMP00000020483, ENST00000280154, OTTHUMT00000050361
    Conserved Domains (1) summary
    smart00544
    Location:327440
    Blast Score: 325
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  3. NM_145341.3NP_663314.1  programmed cell death protein 4 isoform 2

    See proteins identical to NP_663314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region and utilizes a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK315295, AL136368, AL158163, BX647834, DB241608
    Consensus CDS
    CCDS44478.1
    UniProtKB/Swiss-Prot
    Q53EL6
    Related
    ENSP00000376816, ENST00000393104
    Conserved Domains (1) summary
    smart00544
    Location:316429
    Blast Score: 325
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11

    Range
    110871795..110900006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269702.1XP_005269759.1  

    See proteins identical to XP_005269759.1

    Conserved Domains (1) summary
    smart00544
    Location:141254
    Blast Score: 316
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  2. XM_006717767.1XP_006717830.1  

    See proteins identical to XP_006717830.1

    Conserved Domains (1) summary
    smart00544
    Location:141254
    Blast Score: 316
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

Alternate HuRef

Genomic

  1. AC_000142.1 Alternate HuRef

    Range
    106260410..106288621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    112913378..112941587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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