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    RNF115 ring finger protein 115 [ Homo sapiens (human) ]

    Gene ID: 27246, updated on 9-Jun-2013
    Official Symbol
    RNF115provided by HGNC
    Official Full Name
    ring finger protein 115provided by HGNC
    Primary source
    HGNC:18154
    See related
    HPRD:18328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCA2; ZNF364
    Location :
    1q21.1
    Sequence :
    Chromosome: 1; NC_000001.10 (145611036..145688776)
    See RNF115 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT, 3 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C (62kD) Neighboring gene CD160 molecule Neighboring gene PDZ domain containing 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353.
    2. BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. Ehsani L, et al. Tumour Biol, 2013 Apr. PMID 23242606.
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    4. Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor. Kona FR, et al. Breast Cancer Res Treat, 2012 Sep. PMID 22850893.
    5. Rabring7 degrades c-Myc through complex formation with MM-1. Narita R, et al. PLoS One, 2012. PMID 22844532.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. High BCA2 expression is associated with renal oncocytoma.
      Title: BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms.
    2. BCA2 is therefore a newly identified transcriptional target of estrogen receptor.
      Title: Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor.
    3. Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1
      Title: Rabring7 degrades c-Myc through complex formation with MM-1.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. BCA2 accelerates the internalization and degradation of viral particles following their tethering to the cell surface and is a co-factor or enhancer for the tetherin-dependent restriction of HIV-1 release from infected cells.
      Title: BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    7. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity.
      Title: Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.
    8. BCA2 E3 ligase is coregulated with estrogen receptor and plays a role in the regulation of epidermal growth factor receptor (EGF-R) trafficking
      Title: Novel RING E3 ubiquitin ligases in breast cancer.
    9. The autoubiquitination activity of BCA2 indicates that it is a novel RING-type E3 ligase.
      Title: A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Gag, Pr55 gag BCA2 co-localizes with HIV-1 Gag in in CD63+ endosomes/lysosomes PubMed
    Vpu, p16 vpu HIV-1 Vpu antagonizes the effects of BCA2 on HIV-1 particle production in "tetherin-positive" cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y4L5 P51149 RAB7A    HPRD  PubMed  
    Q9Y4L5 O60232 SSSCA1    HPRD  PubMed  
    BioGRID:118094 BioGRID:106710 AKT1    BioGRID  PubMed Biochemical Activity 
    BioGRID:118094 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:118094 BioGRID:108156 ATN1    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:114128 CDK10    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:107853 CST3    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:115081 DOCK4    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:118094 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:118094 BioGRID:108635 FOLR3    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:109501 HRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:109714 IGHA1    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:110397 MFAP4    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:118094 BioGRID:111226 PFDN5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:118094 BioGRID:113624 RAB7A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:118094 BioGRID:130725 RAB7B    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:118094 BioGRID:111823 RAD23A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:118094 BioGRID:118094 RNF115    BioGRID  PubMed Biochemical Activity 
    BioGRID:118094 BioGRID:112062 RPL18A    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:118094 BioGRID:113127 TTR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:118094 BioGRID:113159 UBA52    BioGRID  PubMed PCA; Two-hybrid 
    BioGRID:118094 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; PCA; Reconstituted Complex; Two-hybrid 
    BioGRID:118094 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:113170 UBE2D2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:118094 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:115740 UBE2E3    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:118094 BioGRID:113182 UBE2N    BioGRID  PubMed Reconstituted Complex 
    BioGRID:118094 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Preferred Names
    E3 ubiquitin-protein ligase RNF115
    Names
    E3 ubiquitin-protein ligase RNF115
    rabring 7
    zinc finger protein 364

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014455.2 → NP_055270.1  E3 ubiquitin-protein ligase RNF115

      Status: VALIDATED

      Source sequence(s)
      AF419857, AK290749, AL079312
      Consensus CDS
      CCDS922.1
      UniProtKB/Swiss-Prot
      Q9Y4L5
      Conserved Domains (2) summary
      cd00162
      Location:227 – 272
      Blast Score: 130
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam14369
      Location:18 – 49
      Blast Score: 110
      zf-RING_3; zinc-finger

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_003871055.2 Reference GRCh37.p10 PATCHES

      Range
      2486816..2564582, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      145611036..145688776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      119574598..119652546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      152219768..152297534, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01005739.1 (357..45150) None
    genomic ABBA01005740.1 None
    genomic ABBA01005741.1 None
    genomic AC239808.3 (40009..112433) None
    genomic AC242845.1 (201722..207063) None
    genomic AL160282.18 (172460..191594) None
    genomic AL390725.16 CAI13717.1
    genomic AMYH01001373.1 (355722..433488) None
    genomic CH471244.1 EAW71437.1
      EAW71438.1
    genomic CQ834134.1 CAH05282.1
    mRNA AF419857.1 AAP97292.1
    mRNA AF542552.1 AAQ09535.1
    mRNA AK290749.1 BAF83438.1
    mRNA AL079312.1 None
    mRNA AL079314.1 CAB45280.1
    mRNA BC054049.2 AAH54049.1
    mRNA BC064903.1 AAH64903.1
    other-genetic EU446627.1 ABZ92156.1
    other-genetic EU446791.1 ABZ92320.1
    other-genetic GQ129333.1 ACT64467.1
    other-genetic GQ129334.1 ACT64468.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y4L5.2 GenPept UniProtKB/Swiss-Prot:Q9Y4L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
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      • BioAssay
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      • BioProjects
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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