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SERP1 stress-associated endoplasmic reticulum protein 1 [ Homo sapiens (human) ]

Gene ID: 27230, updated on 8-May-2016
Official Symbol
SERP1provided by HGNC
Official Full Name
stress-associated endoplasmic reticulum protein 1provided by HGNC
Primary source
HGNC:HGNC:10759
See related
Ensembl:ENSG00000120742 HPRD:18037; Vega:OTTHUMG00000159769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAMP4
Orthologs
Location:
3q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (150541993..150603177, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150259780..150264428, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374154 Neighboring gene long intergenic non-protein coding RNA 1214 Neighboring gene TSC22 domain family member 2 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene Sin3A associated protein 30kDa pseudogene Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene ERICH6 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates SERP1 expression in neuron cells PubMed
Vpr vpr The RNA and protein levels of stress-associated endoplasmic reticulum protein 1 (SERP1) decreases in Vpr-treated human neurons compared to the untreated control PubMed

Go to the HIV-1, Human Interaction Database

  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117327, MGC133321, MGC133322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
plasma membrane organization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of growth hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to stress TAS
Traceable Author Statement
more info
PubMed 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
ribosome TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
stress-associated endoplasmic reticulum protein 1
Names
ribosome associated membrane protein 4
ribosome-attached membrane protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014445.3NP_055260.1  stress-associated endoplasmic reticulum protein 1

    See identical proteins and their annotated locations for NP_055260.1

    Status: VALIDATED

    Source sequence(s)
    AA890577, AC107426, BC108314, DB022941
    Consensus CDS
    CCDS3150.1
    UniProtKB/Swiss-Prot
    Q9Y6X1
    Related
    ENSP00000239944, ENST00000239944
    Conserved Domains (1) summary
    pfam06624
    Location:164
    RAMP4; Ribosome associated membrane protein RAMP4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    150541993..150603177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512698.1XP_011511000.1  

    See identical proteins and their annotated locations for XP_011511000.1

    UniProtKB/Swiss-Prot
    Q9Y6X1
    Related
    ENSP00000420076, OTTHUMP00000216427, ENST00000479209, OTTHUMT00000357239
    Conserved Domains (1) summary
    pfam06624
    Location:164
    RAMP4; Ribosome associated membrane protein RAMP4

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    150222832..150227480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)