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SIGLEC8 sialic acid binding Ig like lectin 8 [ Homo sapiens (human) ]

Gene ID: 27181, updated on 26-May-2016
Official Symbol
SIGLEC8provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 8provided by HGNC
Primary source
HGNC:HGNC:10877
See related
Ensembl:ENSG00000105366 HPRD:16132; MIM:605639; Vega:OTTHUMG00000182776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAF2; SIGLEC-8; SIGLEC8L
Summary
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
Orthologs
Location:
19q13.33-q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (51450997..51458454, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51954251..51961708, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372446 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 6 Neighboring gene sialic acid binding Ig like lectin 10 Neighboring gene uncharacterized LOC100129083 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene Neighboring gene sialic acid binding Ig like lectin 26, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC59785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sialic acid-binding Ig-like lectin 8
Names
CDw329
SAF-2
sialic acid binding Ig-like lectin 8
sialoadhesin family member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014442.2NP_055257.2  sialic acid-binding Ig-like lectin 8 precursor

    See identical proteins and their annotated locations for NP_055257.2

    Status: VALIDATED

    Source sequence(s)
    AF195092, BC053319, DA388103
    Consensus CDS
    CCDS33086.1
    UniProtKB/Swiss-Prot
    Q9NYZ4
    Related
    ENSP00000321077, OTTHUMP00000270166, ENST00000321424, OTTHUMT00000463648
    Conserved Domains (2) summary
    smart00410
    Location:269344
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    51450997..51458454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526735.1XP_011525037.1  

    See identical proteins and their annotated locations for XP_011525037.1

    UniProtKB/Swiss-Prot
    Q9NYZ4
    Related
    ENSP00000339448, OTTHUMP00000271838, ENST00000340550, OTTHUMT00000466884
    Conserved Domains (2) summary
    smart00410
    Location:176251
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain
  2. XM_011526734.1XP_011525036.1  

    Conserved Domains (2) summary
    smart00410
    Location:258333
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    51956163..51963620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)