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IL37 interleukin 37 [ Homo sapiens (human) ]

Gene ID: 27178, updated on 8-May-2016
Official Symbol
IL37provided by HGNC
Official Full Name
interleukin 37provided by HGNC
Primary source
HGNC:HGNC:15563
See related
Ensembl:ENSG00000125571 HPRD:05695; MIM:605510; Vega:OTTHUMG00000131345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q12-q14.1
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (112911064..112918882)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113670548..113676459)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase pseudogene Neighboring gene uncharacterized LOC105373563 Neighboring gene cyclin-dependent kinase 8 pseudogene Neighboring gene interleukin 36, gamma Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of lung function phenotypes in a founder population.
NHGRI GWA Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
interleukin-1 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-1 receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
interleukin-37
Names
FIL1 zeta
IL-1 zeta
IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
IL-1X protein
IL1F7 (canonical product IL-1F7b)
interleukin 1 family member 7
interleukin 1, zeta
interleukin-1 homolog 4
interleukin-1 superfamily z
interleukin-1-related protein
interleukin-23

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029219.1 RefSeqGene

    Range
    5001..10912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014439.3NP_055254.2  interleukin-37 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055254.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF167368
    Consensus CDS
    CCDS2103.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263326, OTTHUMP00000162032, ENST00000263326, OTTHUMT00000254126
    Conserved Domains (1) summary
    cl00094
    Location:59204
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_173202.1NP_775294.1  interleukin-37 isoform 2

    See identical proteins and their annotated locations for NP_775294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1, resulting an isoform (2) that lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AB451333, AF167368
    Consensus CDS
    CCDS2104.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263327, OTTHUMP00000162033, ENST00000352179, OTTHUMT00000254127
    Conserved Domains (1) summary
    cl00094
    Location:38183
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  3. NM_173203.1NP_775295.1  interleukin-37 isoform 3

    See identical proteins and their annotated locations for NP_775295.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons but maintains the reading frame, compared to variant 1, resulting an isoform (3) that lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AF167368, AY071841
    Consensus CDS
    CCDS2105.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263328, OTTHUMP00000162034, ENST00000349806, OTTHUMT00000254128
    Conserved Domains (1) summary
    cl00094
    Location:47143
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  4. NM_173204.1NP_775296.1  interleukin-37 isoform 4

    See identical proteins and their annotated locations for NP_775296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame coding exon, compared to variant 1, resulting an isoform (4) that lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AF167368
    Consensus CDS
    CCDS2106.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000309208, OTTHUMP00000162035, ENST00000353225, OTTHUMT00000254129
    Conserved Domains (1) summary
    cl00094
    Location:68164
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  5. NM_173205.1NP_775297.1  interleukin-37 isoform 5

    See identical proteins and their annotated locations for NP_775297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence, compared to variant 1. The resulting isoform (5) has a distinct and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AF167368, AF201832
    Consensus CDS
    CCDS2107.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000309883, OTTHUMP00000162036, ENST00000311328, OTTHUMT00000254130
    Conserved Domains (1) summary
    cl00094
    Location:33178
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    112911064..112918882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510964.1XP_011509266.1  

    See identical proteins and their annotated locations for XP_011509266.1

    UniProtKB/Swiss-Prot
    Q9NZH6
    Conserved Domains (1) summary
    cl00094
    Location:68164
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. XM_011510963.1XP_011509265.1  

    See identical proteins and their annotated locations for XP_011509265.1

    UniProtKB/Swiss-Prot
    Q9NZH6
    Conserved Domains (1) summary
    cl00094
    Location:59204
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    113674704..113680616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)