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SLC39A1 solute carrier family 39 member 1 [ Homo sapiens (human) ]

Gene ID: 27173, updated on 8-May-2016
Official Symbol
SLC39A1provided by HGNC
Official Full Name
solute carrier family 39 member 1provided by HGNC
Primary source
HGNC:HGNC:12876
See related
Ensembl:ENSG00000143570 HPRD:11984; MIM:604740; Vega:OTTHUMG00000037158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP1; ZIRTL
Summary
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Orthologs
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (153959099..153968184, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153931575..153940660, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928059 Neighboring gene DENN domain containing 4B Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene microRNA 6737 Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene jumping translocation breakpoint Neighboring gene RAB13, member RAS oncogene family

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inorganic cation transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cation transport TAS
Traceable Author Statement
more info
PubMed 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
zinc II ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
zinc transporter ZIP1
Names
solute carrier family 39 (zinc transporter), member 1
solute carrier family 39 (zinc transporter), member 3
zrt- and Irt-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271957.1NP_001258886.1  zinc transporter ZIP1 isoform a

    See identical proteins and their annotated locations for NP_001258886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AF132942, AK074943, AW571711, BG704399, DA354647
    Consensus CDS
    CCDS1055.1
    UniProtKB/Swiss-Prot
    Q9NY26
    Related
    ENSP00000357610, OTTHUMP00000035261, ENST00000368621, OTTHUMT00000090286
    Conserved Domains (1) summary
    pfam02535
    Location:59319
    Zip; ZIP Zinc transporter
  2. NM_001271958.1NP_001258887.1  zinc transporter ZIP1 isoform a

    See identical proteins and their annotated locations for NP_001258887.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AF132942, AK075257, AW571711, BC014303, DA052424, DA818910
    Consensus CDS
    CCDS1055.1
    UniProtKB/Swiss-Prot
    Q9NY26
    Related
    ENSP00000348535, OTTHUMP00000035258, ENST00000356205, OTTHUMT00000090283
    Conserved Domains (1) summary
    pfam02535
    Location:59319
    Zip; ZIP Zinc transporter
  3. NM_001271959.1NP_001258888.1  zinc transporter ZIP1 isoform a

    See identical proteins and their annotated locations for NP_001258888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AF151829, AW571711, DA711655, HY042960
    Consensus CDS
    CCDS1055.1
    UniProtKB/Swiss-Prot
    Q9NY26
    Related
    ENSP00000484182, ENST00000621013
    Conserved Domains (1) summary
    pfam02535
    Location:59319
    Zip; ZIP Zinc transporter
  4. NM_001271960.1NP_001258889.1  zinc transporter ZIP1 isoform a

    See identical proteins and their annotated locations for NP_001258889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AW571711, BC014303, DB001496
    Consensus CDS
    CCDS1055.1
    UniProtKB/Swiss-Prot
    Q9NY26
    Related
    ENSP00000479421, ENST00000617697
    Conserved Domains (1) summary
    pfam02535
    Location:59319
    Zip; ZIP Zinc transporter
  5. NM_001271961.1NP_001258890.1  zinc transporter ZIP1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK293389, AW571711, BM807264, DA052424, DA818910
    Consensus CDS
    CCDS72920.1
    UniProtKB/Swiss-Prot
    Q9NY26
    UniProtKB/TrEMBL
    A0A0A0MTL8
    Related
    ENSP00000443632, ENST00000537590
  6. NM_014437.4NP_055252.2  zinc transporter ZIP1 isoform a

    See identical proteins and their annotated locations for NP_055252.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, 4 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AL358472, AW571711, BC014303
    Consensus CDS
    CCDS1055.1
    UniProtKB/Swiss-Prot
    Q9NY26
    Related
    ENSP00000309710, OTTHUMP00000035260, ENST00000310483, OTTHUMT00000090285
    Conserved Domains (1) summary
    pfam02535
    Location:59319
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    153959099..153968184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    155327888..155336973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)