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ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) [ Homo sapiens (human) ]

Gene ID: 27109, updated on 26-May-2016
Official Symbol
ATP5Sprovided by HGNC
Official Full Name
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)provided by HGNC
Primary source
HGNC:HGNC:18799
See related
Ensembl:ENSG00000125375 HPRD:12503; Vega:OTTHUMG00000170866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FB; ATPW; HSU79253
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (50312329..50326715)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50778256..50802359)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene uncharacterized LOC105370486 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene microRNA 4504 Neighboring gene cyclin dependent kinase like 1 Neighboring gene uncharacterized LOC105370487 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene zinc finger protein 678 pseudogene

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrogen ion transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
proton transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ATP synthase subunit s, mitochondrial
Names
ATP synthase coupling factor B, mitochondrial
ATP synthase coupling factor B-like 1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase-coupling factor B
mitochondrial ATP synthase regulatory component factor B
NP_001003803.1
NP_001003805.1
NP_056499.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003803.2NP_001003803.1  ATP synthase subunit s, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001003803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest protein-coding transcript, and encodes the longest isoform (a).
    Source sequence(s)
    AK290008, BC011549, CD517203, DA033027
    Consensus CDS
    CCDS32075.1
    UniProtKB/Swiss-Prot
    Q99766
    Related
    ENSP00000308334, OTTHUMP00000244614, ENST00000311459, OTTHUMT00000410761
    Conserved Domains (2) summary
    pfam13855
    Location:124187
    LRR_8; Leucine rich repeat
    sd00034
    Location:126150
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_001003805.2NP_001003805.1  ATP synthase subunit s, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001003805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the coding region which leads to a frameshift, compared to variant 1. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC011549, BU189283, DA033027
    Consensus CDS
    CCDS32076.1
    UniProtKB/Swiss-Prot
    Q99766
    Related
    ENSP00000245448, OTTHUMP00000244611, ENST00000245448, OTTHUMT00000410756
  3. NM_015684.3NP_056499.2  ATP synthase subunit s, mitochondrial isoform c precursor

    See identical proteins and their annotated locations for NP_056499.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF052186, BI755956, BU189283, DA033027
    Consensus CDS
    CCDS45102.1
    UniProtKB/Swiss-Prot
    Q99766
    Related
    ENSP00000389246, OTTHUMP00000244612, ENST00000426751, OTTHUMT00000410759

RNA

  1. NR_033761.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC011549, BU189283, DA033027

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    50312329..50326715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536656.1XP_011534958.1  

    See identical proteins and their annotated locations for XP_011534958.1

    UniProtKB/Swiss-Prot
    Q99766
  2. XM_011536655.1XP_011534957.1  

    See identical proteins and their annotated locations for XP_011534957.1

  3. XM_011536649.1XP_011534951.1  

    Conserved Domains (2) summary
    pfam13855
    Location:153216
    LRR_8; Leucine rich repeat
    sd00034
    Location:155179
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. XM_011536651.1XP_011534953.1  

  5. XM_011536650.1XP_011534952.1  

  6. XM_011536654.1XP_011534956.1  

    See identical proteins and their annotated locations for XP_011534956.1

  7. XM_011536652.1XP_011534954.1  

    Conserved Domains (1) summary
    sd00034
    Location:116140
    LRR_AMN1; leucine-rich repeat [structural motif]
  8. XM_011536657.1XP_011534959.1  

  9. XM_011536653.1XP_011534955.1  

    See identical proteins and their annotated locations for XP_011534955.1

    Conserved Domains (1) summary
    sd00034
    Location:111135
    LRR_AMN1; leucine-rich repeat [structural motif]
  10. XM_005267537.2XP_005267594.1  

    See identical proteins and their annotated locations for XP_005267594.1

    Conserved Domains (1) summary
    sd00034
    Location:111135
    LRR_AMN1; leucine-rich repeat [structural motif]

RNA

  1. XR_943415.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    50717681..50731593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)