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TPK1 thiamin pyrophosphokinase 1 [ Homo sapiens (human) ]

Gene ID: 27010, updated on 26-May-2016
Official Symbol
TPK1provided by HGNC
Official Full Name
thiamin pyrophosphokinase 1provided by HGNC
Primary source
HGNC:HGNC:17358
See related
Ensembl:ENSG00000196511 HPRD:06967; MIM:606370; Vega:OTTHUMG00000152774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP20; HTPK1; THMD5
Summary
This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7q34-q35
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (144451941..144836411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (144149034..144533488, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NOBOX oogenesis homeobox Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 10 Neighboring gene uncharacterized LOC105375552 Neighboring gene EI24, autophagy associated transmembrane protein pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of thiamin pyrophosphokinase 1 (TPK1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of thiamin pyrophosphokinase 1 (TPK1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
thiamine binding IEA
Inferred from Electronic Annotation
more info
 
thiamine diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
thiamine diphosphokinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
thiamine diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
thiamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
thiamine-containing compound metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
thiamin pyrophosphokinase 1
Names
placental protein 20
thiamine diphosphokinase
thiamine kinase
NP_001035947.1
NP_071890.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032112.1 RefSeqGene

    Range
    5001..389113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042482.1NP_001035947.1  thiamin pyrophosphokinase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC004534, BC040555, BI770816, BX446289, DA135998
    Consensus CDS
    CCDS55178.1
    UniProtKB/Swiss-Prot
    Q9H3S4
    UniProtKB/TrEMBL
    F5GZG6
    Related
    ENSP00000367339, ENST00000378099
    Conserved Domains (2) summary
    cd07995
    Location:20190
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21192
    PLN02714; thiamin pyrophosphokinase
  2. NM_022445.3NP_071890.2  thiamin pyrophosphokinase 1 isoform a

    See identical proteins and their annotated locations for NP_071890.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF297710, BC040555, DA135998
    Consensus CDS
    CCDS5888.1
    UniProtKB/Swiss-Prot
    Q9H3S4
    UniProtKB/TrEMBL
    A0A090N8Y0
    Related
    ENSP00000353165, OTTHUMP00000202345, ENST00000360057, OTTHUMT00000327777
    Conserved Domains (2) summary
    cd07995
    Location:20239
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21241
    PLN02714; thiamin pyrophosphokinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    144451941..144836411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516033.1XP_011514335.1  

    See identical proteins and their annotated locations for XP_011514335.1

    Conserved Domains (2) summary
    cd07995
    Location:20265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21267
    PLN02714; thiamin pyrophosphokinase
  2. XM_005249970.1XP_005250027.1  

    See identical proteins and their annotated locations for XP_005250027.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    UniProtKB/TrEMBL
    A0A090N8Y0
    Conserved Domains (2) summary
    cd07995
    Location:20239
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21241
    PLN02714; thiamin pyrophosphokinase
  3. XM_011516034.1XP_011514336.1  

    See identical proteins and their annotated locations for XP_011514336.1

    Conserved Domains (2) summary
    cd07995
    Location:20265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21267
    PLN02714; thiamin pyrophosphokinase
  4. XM_011516043.1XP_011514345.1  

    Conserved Domains (2) summary
    cd07995
    Location:20216
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21218
    PLN02714; thiamin pyrophosphokinase
  5. XM_011516031.1XP_011514333.1  

    See identical proteins and their annotated locations for XP_011514333.1

    Conserved Domains (2) summary
    cd07995
    Location:20265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21267
    PLN02714; thiamin pyrophosphokinase
  6. XM_011516032.1XP_011514334.1  

    See identical proteins and their annotated locations for XP_011514334.1

    Conserved Domains (2) summary
    cd07995
    Location:20265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21267
    PLN02714; thiamin pyrophosphokinase
  7. XM_011516036.1XP_011514338.1  

    See identical proteins and their annotated locations for XP_011514338.1

    Conserved Domains (2) summary
    cd07995
    Location:58260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19260
    thi_PPkinase; thiamine pyrophosphokinase
  8. XM_011516037.1XP_011514339.1  

    See identical proteins and their annotated locations for XP_011514339.1

    Conserved Domains (2) summary
    cd07995
    Location:58260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19260
    thi_PPkinase; thiamine pyrophosphokinase
  9. XM_011516039.1XP_011514341.1  

    Conserved Domains (1) summary
    cd07995
    Location:33239
    TPK; Thiamine pyrophosphokinase
  10. XM_011516041.1XP_011514343.1  

    Conserved Domains (2) summary
    cd07995
    Location:58234
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19234
    thi_PPkinase; thiamine pyrophosphokinase
  11. XM_011516045.1XP_011514347.1  

    Conserved Domains (1) summary
    cd07995
    Location:2159
    TPK; Thiamine pyrophosphokinase
  12. XM_011516038.1XP_011514340.1  

    See identical proteins and their annotated locations for XP_011514340.1

    Conserved Domains (2) summary
    cd07995
    Location:58260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19260
    thi_PPkinase; thiamine pyrophosphokinase
  13. XM_011516049.1XP_011514351.1  

    See identical proteins and their annotated locations for XP_011514351.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    cd07995
    Location:9133
    TPK; Thiamine pyrophosphokinase
  14. XM_006715925.2XP_006715988.1  

    See identical proteins and their annotated locations for XP_006715988.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    cd07995
    Location:9133
    TPK; Thiamine pyrophosphokinase
  15. XM_011516044.1XP_011514346.1  

    See identical proteins and their annotated locations for XP_011514346.1

    UniProtKB/TrEMBL
    Q6ZQX6
    Related
    ENSP00000438813, OTTHUMP00000241341, ENST00000538212, OTTHUMT00000404403
    Conserved Domains (2) summary
    cd07995
    Location:58185
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19185
    thi_PPkinase; thiamine pyrophosphokinase
  16. XM_011516047.1XP_011514349.1  

    See identical proteins and their annotated locations for XP_011514349.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    cd07995
    Location:9133
    TPK; Thiamine pyrophosphokinase
  17. XM_011516050.1XP_011514352.1  

    See identical proteins and their annotated locations for XP_011514352.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    cd07995
    Location:9133
    TPK; Thiamine pyrophosphokinase
  18. XM_011516048.1XP_011514350.1  

    See identical proteins and their annotated locations for XP_011514350.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    cd07995
    Location:9133
    TPK; Thiamine pyrophosphokinase
  19. XM_011516035.1XP_011514337.1  

    Conserved Domains (2) summary
    cd07995
    Location:20230
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:21247
    thi_PPkinase; thiamine pyrophosphokinase
  20. XM_011516040.1XP_011514342.1  

    Conserved Domains (1) summary
    cd07995
    Location:20230
    TPK; Thiamine pyrophosphokinase
  21. XM_011516042.1XP_011514344.1  

    Conserved Domains (1) summary
    cd07995
    Location:20232
    TPK; Thiamine pyrophosphokinase
  22. XM_011516046.1XP_011514348.1  

    Related
    ENSP00000367338, OTTHUMP00000202346, ENST00000378098, OTTHUMT00000327778
    Conserved Domains (1) summary
    pfam04263
    Location:25140
    TPK_catalytic; Thiamin pyrophosphokinase, catalytic domain

RNA

  1. XR_927453.1 RNA Sequence

  2. XR_927448.1 RNA Sequence

  3. XR_927446.1 RNA Sequence

  4. XR_927450.1 RNA Sequence

  5. XR_927451.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    144157512..144541732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)