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    USP21 ubiquitin specific peptidase 21 [ Homo sapiens ]

    Gene ID: 27005, updated on 11-May-2012
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    Summary

    Official Symbol
    USP21provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 21provided by HGNC
    Primary source
    HGNC:12620
    Locus tag
    RP11-297K8.3
    See related
    Ensembl:ENSG00000143258; HPRD:05291; MIM:604729; Vega:OTTHUMG00000033154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP16; USP23; MGC3394
    Summary
    This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q22
    Sequence :
    Chromosome: 1; NC_000001.10 (161129254..161135516)
    See USP21 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene protoporphyrinogen oxidase Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. Ye Y, et al. EMBO Rep, 2011 Apr. PMID 21399617.
    4. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Bremm A, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20622874.
    5. Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. Xu G, et al. J Biol Chem, 2010 Jan 8. PMID 19910467.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Study report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15, but is inactive against NEDD8.
      Title: Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
    2. USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1.
      Title: Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UK80 Q01780 EXOSC10    HPRD  PubMed  
    BioGRID:117950 BioGRID:116847 ANKRD28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:121704 BEND3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:108793 FUCA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:110309 MARK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:111475 PPIB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:111570 PRKCI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:126210 RBM45    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:115265 RBM8A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117950 BioGRID:113041 TRAF6    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:117950 BioGRID:118150 UBE2S    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:122396 UPF3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:116077 USP20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:123941 USP48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:113245 UTRN    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NEDD8-specific protease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin thiolesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ubiquitin thiolesterase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein modification process NAS
    Non-traceable Author Statement
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    ubiquitin carboxyl-terminal hydrolase 21
    NEDD8-specific protease
    ubiquitin thioesterase 21
    deubiquitinating enzyme 21
    ubiquitin thiolesterase 21
    ubiquitin specific protease 21
    ubiquitin-specific protease 16
    ubiquitin-specific processing protease 21
    ubiquitin-specific-processing protease 21
    NP_001014443.1
    NP_036607.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014443.2 → NP_001014443.1  ubiquitin carboxyl-terminal hydrolase 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF177758, AI038040, BC090946, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000356981, ENST00000368002
      Conserved Domains (3) summary
      cd02674
      Location:298 – 556
      Blast Score: 587
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:213 – 234
      Blast Score: 116
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212 – 555
      Blast Score: 694
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_012475.4 → NP_036607.3  ubiquitin carboxyl-terminal hydrolase 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF177758, AI038040, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000289865, OTTHUMP00000031883, ENST00000289865, OTTHUMT00000080801
      Conserved Domains (3) summary
      cd02674
      Location:298 – 556
      Blast Score: 587
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:213 – 234
      Blast Score: 116
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212 – 555
      Blast Score: 694
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      161129254..161135516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      132486196..132492458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL590714.27 CAH72142.1
      CAH72143.1
    genomic CH471121.2 EAW52642.1
      EAW52643.1
      EAW52644.1
      EAW52645.1
    mRNA AB208899.1 BAD92136.1
    mRNA AF177758.1 AAD54321.1
    mRNA AF217979.1 AAG17222.1
    mRNA AF233442.1 AAF61308.1
    mRNA AI038040.1 None
    mRNA AK292319.1 BAF85008.1
    mRNA AK310326.1 None
    mRNA AL157417.1 CAB75649.1
    mRNA BC003130.1 AAH03130.2
    mRNA BC090946.1 AAH90946.1
    mRNA BC136291.1 AAI36292.1
    mRNA BI463191.1 None
    mRNA BI755746.1 None
    mRNA BM742944.1 None
    mRNA N76159.1 None
    mRNA T77123.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSS9 GenPept UniProtKB/TrEMBL:Q9NSS9
    Q9UK80.1 GenPept UniProtKB/Swiss-Prot:Q9UK80
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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