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    USP21 ubiquitin specific peptidase 21 [ Homo sapiens (human) ]

    Gene ID: 27005, updated on 5-May-2013
    Official Symbol
    USP21provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 21provided by HGNC
    Primary source
    HGNC:12620
    Locus tag
    RP11-297K8.3
    See related
    Ensembl:ENSG00000143258; HPRD:05291; MIM:604729; Vega:OTTHUMG00000033154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP16; USP23
    Summary
    This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
    Location :
    1q22
    Sequence :
    Chromosome: 1; NC_000001.10 (161129254..161135516)
    See USP21 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene protoporphyrinogen oxidase Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UK80 Q01780 EXOSC10    HPRD  PubMed  
    BioGRID:117950 BioGRID:116847 ANKRD28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:114618 ARHGEF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:110433 ATXN3    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113911 BAP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:121704 BEND3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:107315 CBL    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:117156 CBLC    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:115137 CKAP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:128203 DTX3    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:199230 Dlg4    BioGRID  PubMed Protein-peptide 
    BioGRID:117950 BioGRID:115052 ESPL1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:108793 FUCA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:114995 ISG15    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:115257 JOSD1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:124754 LRSAM1    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:110306 MAP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:110309 MARK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117950 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117950 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:120751 OTUB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:122461 OTUB2    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:123896 PCGF6    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:111475 PPIB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:111570 PRKCI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:115862 RBCK1    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:126210 RBM45    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:115265 RBM8A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117950 BioGRID:115125 RNF144A    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:124834 RNF185    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:117594 SENP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:125819 SENP8    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:115863 STAMBP    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113041 TRAF6    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:106868 TRIM23    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:124491 TRIM5    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:121415 TRIM54    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:124195 TRIM63    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:123541 TRIM8    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:125280 TRIM9    BioGRID  PubMed Two-hybrid 
    BioGRID:117950 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:117950 BioGRID:118150 UBE2S    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:117950 BioGRID:113194 UCHL3    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:122396 UPF3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:114551 USP14    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:115283 USP15    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:114553 USP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:116077 USP20    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:117950 BioGRID:117950 USP21    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:121683 USP28    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:116671 USP33    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113221 USP4    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:123941 USP48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:127720 USP51    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113622 USP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:114555 USP8    BioGRID  PubMed Biochemical Activity 
    BioGRID:117950 BioGRID:113245 UTRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117950 BioGRID:113348 XPO1    BioGRID  PubMed Co-localization 
    BioGRID:117950 BioGRID:120666 YOD1    BioGRID  PubMed Biochemical Activity 
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...

    Markers

    Homology

    Clone Names

    • MGC3394

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NEDD8-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin thiolesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin thiolesterase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein modification process NAS
    Non-traceable Author Statement
    more info
     
    histone deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    ubiquitin carboxyl-terminal hydrolase 21
    NEDD8-specific protease
    ubiquitin thioesterase 21
    deubiquitinating enzyme 21
    ubiquitin thiolesterase 21
    ubiquitin specific protease 21
    ubiquitin-specific protease 16
    ubiquitin-specific processing protease 21
    ubiquitin-specific-processing protease 21
    NP_001014443.1
    NP_036607.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014443.2NP_001014443.1  ubiquitin carboxyl-terminal hydrolase 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF177758, AI038040, BC090946, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000356981, ENST00000368002
      Conserved Domains (3) summary
      cd02674
      Location:298556
      Blast Score: 587
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:213234
      Blast Score: 116
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212555
      Blast Score: 694
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_012475.4NP_036607.3  ubiquitin carboxyl-terminal hydrolase 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF177758, AI038040, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000289865, OTTHUMP00000031883, ENST00000289865, OTTHUMT00000080801
      Conserved Domains (3) summary
      cd02674
      Location:298556
      Blast Score: 587
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:213234
      Blast Score: 116
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212555
      Blast Score: 694
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      161129254..161135516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      132486196..132492458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      167625509..167631771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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