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    ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens (human) ]

    Gene ID: 27, updated on 18-May-2013
    Official Symbol
    ABL2provided by HGNC
    Official Full Name
    v-abl Abelson murine leukemia viral oncogene homolog 2provided by HGNC
    Primary source
    HGNC:77
    Locus tag
    RP11-177A2.3
    See related
    Ensembl:ENSG00000143322; HPRD:01259; MIM:164690; Vega:OTTHUMG00000035199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARG; ABLL
    Summary
    This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
    Location :
    1q25.2
    Sequence :
    Chromosome: 1; NC_000001.10 (179068462..179198819, complement)
    See ABL2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 20, member B Neighboring gene ribosomal protein S26 pseudogene 16 Neighboring gene torsin family 3, member A Neighboring gene SET pseudogene 10 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 11 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) pseudogene Neighboring gene cytochrome c oxidase subunit Vb pseudogene 8 Neighboring gene ribosomal protein L39 pseudogene 11

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Liu BA, et al. Cell Commun Signal, 2012 Sep 14. PMID 22974441.
    2. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
    3. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. Ramasamy A, et al. J Allergy Clin Immunol, 2011 Nov. PMID 22036096.
    4. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    5. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Ganguly SS, et al. Oncogene, 2012 Apr 5. PMID 21892207.

    See all (66) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice.
      Title: Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection.
    2. c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo
      Title: c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.
    3. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
      Title: An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.
    4. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways.
      Title: c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    7. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia.
      Title: Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS.
    8. Results describe the NMR structure of human Arg F-actin-binding domain.
      Title: NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.
    9. Abl kinases not only are activated by PDGFR and promote PDGFR-mediated proliferation and migration, but also act in an intricate negative feedback loop to turn-off PDGFR-mediated chemotaxis.
      Title: Reciprocal regulation of Abl and receptor tyrosine kinases.
    10. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity.
      Title: ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.
    Submit: New GeneRIF Correction See all (17)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_009298.1 NP_009297.1 ABL1    BIND  PubMed c-Abl interacts with ARG. 
    NP_009298.1 NP_009297.2 ABL1    BIND  PubMed ABL1 (c-Abl) phosphorylates ABL2 (Arg). 
    NP_009298.1 NP_009298.1 ABL2    BIND  PubMed ABL2 (Arg) is an autophosphorylating molecule. 
    NP_009298.1 NP_004318.2 BCR    BIND  PubMed BCR interacts with ARG. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human ARG. 
    NP_009298.1 NP_058431.2 CRK    BIND  PubMed ABL2 (Arg) phosphorylates CRK. 
    P42684 P00519 ABL1    HPRD  PubMed  
    P42684 P11274 BCR    HPRD  PubMed  
    P42684 P04040 CAT    HPRD  PubMed  
    P42684 P46108 CRK    HPRD  PubMed  
    P42684 P29323 EPHB2    HPRD  PubMed  
    P42684 P07203 GPX1    HPRD  PubMed  
    P42684 P08631 HCK    HPRD  PubMed  
    P42684 Q13671 RIN1    HPRD  PubMed  
    P42684 O15304 SIVA1    HPRD  PubMed  
    P42684 Arg binding protein 2 SORBS2    HPRD  PubMed  
    BioGRID:106545 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106545 BioGRID:124071 C15orf48    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:107297 CAT    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    NP_058431.2 CRK    BIND  PubMed Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK. 
    BioGRID:106545 BioGRID:107788 CRK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106545 BioGRID:108131 DOK1    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:199230 Dlg4    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:108276 EGFR    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:108362 EPHB2    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:108376 ERBB2    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:108377 ERBB3    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:108378 ERBB4    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:123513 FBXO38    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:109305 HCK    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:119613 HDAC7    BioGRID  PubMed Negative Genetic 
    BioGRID:106545 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106545 BioGRID:110440 MAP3K10    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:123219 MED28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106545 BioGRID:201336 Mbp    BioGRID  PubMed Protein-peptide 
    BioGRID:106545 BioGRID:110811 NEDD4    BioGRID  PubMed Biochemical Activity 
    BioGRID:106545 BioGRID:116915 NEDD4L    BioGRID  PubMed Biochemical Activity 
    BioGRID:106545 BioGRID:116467 OIP5    BioGRID  PubMed Two-hybrid 
    BioGRID:106545 BioGRID:111661 PSMA7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    NP_004283.1 RIN1    BIND  PubMed ABL2 interacts with and phosphorylates RIN1. 
    BioGRID:106545 BioGRID:114047 SORBS2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106545 BioGRID:113017 TPD52L1    BioGRID  PubMed Two-hybrid 
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
      Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ22224, FLJ31718, FLJ41441

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin filament binding TAS
    Traceable Author Statement
    more info
    		  
    actin monomer binding TAS
    Traceable Author Statement
    more info
    		  
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of actin cytoskeleton reorganization TAS
    Traceable Author Statement
    more info
    		  
    regulation of autophagy TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell motility TAS
    Traceable Author Statement
    more info
    		  
    regulation of endocytosis TAS
    Traceable Author Statement
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    Abelson tyrosine-protein kinase 2
    Names
    Abelson tyrosine-protein kinase 2
    tyrosine-protein kinase ARG
    abelson-related gene protein
    NP_001129472.1
    NP_001129473.1
    NP_001161708.1
    NP_001161709.1
    NP_001161710.1
    NP_001161711.1
    NP_005149.4
    NP_009298.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028242.1 RefSeqGene

      Range
      5001..135358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136000.2 → NP_001129472.1  Abelson tyrosine-protein kinase 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame segment in the 3' coding region, compared to variant b. The resulting isoform (d, also known as 1ALCTS) has a distinct N-terminus and is shorter than isoform b.
      Source sequence(s)
      AL139132, BQ014912, BX538317
      Consensus CDS
      CCDS44282.1
      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (5) summary
      pfam08919
      Location:902 – 1064
      Blast Score: 488
      F_actin_bind; F-actin binding
      cd05052
      Location:266 – 528
      Blast Score: 1416
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:154 – 247
      Blast Score: 498
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:273 – 524
      Blast Score: 1028
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:96 – 149
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    2. NM_001136001.1 → NP_001129473.1  Abelson tyrosine-protein kinase 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame exon in the 5' coding region, and differs in the 3' coding region and 3' UTR, compared to variant b. The resulting isoform (e) has a distinct C-terminus and is shorter than isoform b.
      Source sequence(s)
      AK311045, AL512326, BC065912
      Consensus CDS
      CCDS44283.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000375897, OTTHUMP00000240781, ENST00000392043, OTTHUMT00000360390
      Conserved Domains (4) summary
      cd05052
      Location:260 – 522
      Blast Score: 1384
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:148 – 241
      Blast Score: 487
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:267 – 518
      Blast Score: 1008
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:90 – 143
      Blast Score: 259
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    3. NM_001168236.1 → NP_001161708.1  Abelson tyrosine-protein kinase 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) lacks an alternate in-frame exon in the 5' coding region, compared to variant b, resulting in an isoform (f, also known as 1BSCTL) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542285
      Consensus CDS
      CCDS53436.1
      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (5) summary
      pfam08919
      Location:999 – 1161
      Blast Score: 485
      F_actin_bind; F-actin binding
      cd05052
      Location:260 – 522
      Blast Score: 1421
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:148 – 241
      Blast Score: 499
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:267 – 518
      Blast Score: 1033
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:90 – 143
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    4. NM_001168237.1 → NP_001161709.1  Abelson tyrosine-protein kinase 2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) lacks an alternate in-frame segment in the 3' coding region, compared to variant b, resulting in an isoform (g, also known as 1BLCTS) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542284
      Consensus CDS
      CCDS53438.1
      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (5) summary
      pfam08919
      Location:917 – 1079
      Blast Score: 489
      F_actin_bind; F-actin binding
      cd05052
      Location:281 – 543
      Blast Score: 1416
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:169 – 262
      Blast Score: 498
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:288 – 539
      Blast Score: 1030
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:111 – 164
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    5. NM_001168238.1 → NP_001161710.1  Abelson tyrosine-protein kinase 2 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (h) lacks an alternate in-frame exon in the 5' coding region and an alternate in-frame segment in the 3' coding region, compared to variant b, resulting in an isoform (h, also known as 1BSCTS) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542286
      Consensus CDS
      CCDS53437.1
      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (5) summary
      pfam08919
      Location:896 – 1058
      Blast Score: 488
      F_actin_bind; F-actin binding
      cd05052
      Location:260 – 522
      Blast Score: 1415
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:148 – 241
      Blast Score: 498
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:267 – 518
      Blast Score: 1029
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:90 – 143
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    6. NM_001168239.1 → NP_001161711.1  Abelson tyrosine-protein kinase 2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (i) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame segment in the 3' coding region, compared to variant b. The encoded isoform (i, also known as 1ASCTS) has a distinct N-terminus and is shorter than isoform b.
      Source sequence(s)
      AL139132, BQ014912, BX538317, FJ542283
      Consensus CDS
      CCDS53435.1
      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (5) summary
      pfam08919
      Location:881 – 1043
      Blast Score: 487
      F_actin_bind; F-actin binding
      cd05052
      Location:245 – 507
      Blast Score: 1415
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:133 – 226
      Blast Score: 499
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:252 – 503
      Blast Score: 1027
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:75 – 128
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    7. NM_005158.4 → NP_005149.4  Abelson tyrosine-protein kinase 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and 5' coding region, compared to variant b, resulting in an isoform (c, also known as 1ALCTL) with a distinct and shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AL139132, AL359179, BC065912, BQ014912, BX538317
      Consensus CDS
      CCDS41441.2
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000386152, ENST00000408940
      Conserved Domains (5) summary
      pfam08919
      Location:1005 – 1167
      Blast Score: 485
      F_actin_bind; F-actin binding
      cd05052
      Location:266 – 528
      Blast Score: 1422
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:154 – 247
      Blast Score: 499
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:273 – 524
      Blast Score: 1032
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:96 – 149
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    8. NM_007314.3 → NP_009298.1  Abelson tyrosine-protein kinase 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) represents the longest transcript and encodes the longest isoform (b, also known as 1BLCTL).
      Source sequence(s)
      AL139132, AL512326, BQ014912, M35296
      Consensus CDS
      CCDS30947.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000427562, OTTHUMP00000033139, ENST00000502732, OTTHUMT00000085174
      Conserved Domains (5) summary
      pfam08919
      Location:1020 – 1182
      Blast Score: 486
      F_actin_bind; F-actin binding
      cd05052
      Location:281 – 543
      Blast Score: 1422
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:169 – 262
      Blast Score: 498
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      pfam07714
      Location:288 – 539
      Blast Score: 1034
      Pkinase_Tyr; Protein tyrosine kinase
      cd11850
      Location:111 – 164
      Blast Score: 262
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      179068462..179198819, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      150296029..150426165, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      185622552..185666307, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01027819.1 (3718..8835) None
    genomic ABBA01027820.1 None
    genomic ABBA01027821.1 None
    genomic ABBA01027822.1 None
    genomic ABBA01027823.1 None
    genomic ABBA01027824.1 None
    genomic AL139132.16 (133593..157866) None
    genomic AL359179.18 (2001..5994) None
    genomic AL512326.25 (2007..104096) None
    genomic AMYH01001529.1 (9201..52956) None
    genomic CH471067.1 EAW91040.1
      EAW91041.1
    genomic DQ009672.1 AAY16984.1
    genomic M14904.1 None
    mRNA AK025877.1 None
    mRNA AK056280.1 None
    mRNA AK225255.1 None
    mRNA AK309549.1 None
    mRNA AK311045.1 None
    mRNA BC065912.1 AAH65912.1
    mRNA BQ014912.1 None
    mRNA BX538317.1 CAD98092.1
    mRNA DA596675.1 None
    mRNA DB280398.1 None
    mRNA FJ542283.1 ACK76601.1
    mRNA FJ542284.1 ACK76602.1
    mRNA FJ542285.1 ACK76603.1
    mRNA FJ542286.1 ACK76604.1
    mRNA M35296.1 AAA35553.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42684.1 GenPept UniProtKB/Swiss-Prot:P42684

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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