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    CYFIP2 cytoplasmic FMR1 interacting protein 2 [ Homo sapiens ]

    Gene ID: 26999, updated on 11-May-2012
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    Summary

    Official Symbol
    CYFIP2provided by HGNC
    Official Full Name
    cytoplasmic FMR1 interacting protein 2provided by HGNC
    Primary source
    HGNC:13760
    See related
    Ensembl:ENSG00000055163; HPRD:07556; MIM:606323; Vega:OTTHUMG00000163484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIR121
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    Genomic context

    Location :
    5q33.3
    Sequence :
    Chromosome: 5; NC_000005.9 (156693091..156822606)
    See CYFIP2 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 71, member B Neighboring gene IL2-inducible T-cell kinase Neighboring gene fibronectin type III domain containing 9 Neighboring gene ribosomal protein L26 pseudogene 18 Neighboring gene NIPA-like domain containing 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Mongroo PS, et al. Cancer Res, 2011 Mar 15. PMID 21252116.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Anitei M, et al. Nat Cell Biol, 2010 Apr. PMID 20228810.

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies identify a novel proapoptotic gene target, CYFIP2, which is downregulated by IMP-1, and mediates the regulation of cell survival and K-Ras expression in colon cancer cells.
      Title: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
    2. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network.
      Title: Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population.
    5. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter.
      Title: CYFIP2, a direct p53 target, is leptomycin-B sensitive.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96F07 Q8IZP0 ABI1    HPRD  PubMed  
    Q96F07 Q9P2A4 ABI3    HPRD  PubMed  
    Q96F07 C3orf10 protein BRK1    HPRD  PubMed  
    Q96F07 Q6XZF7 DNMBP    HPRD  PubMed  
    Q96F07 Q06787 FMR1    HPRD  PubMed  
    Q96F07 P51114 FXR1    HPRD  PubMed  
    Q96F07 P51116 FXR2    HPRD  PubMed  
    Q96F07 P16333 NCK1    HPRD  PubMed  
    Q96F07 Q9Y2A7 NCKAP1    HPRD  PubMed  
    Q96F07 Q92558 WASF1    HPRD  PubMed  
    Q96F07 Q8IV90 WASF2    HPRD  PubMed  
    Q96F07 P61981 YWHAG    HPRD  PubMed  
    BioGRID:117945 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:116869 DNMBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:108619 FMR1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:117945 BioGRID:113760 FXR1    BioGRID  PubMed Two-hybrid 
    BioGRID:117945 BioGRID:114094 GAS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:3423 GRL    BioGRID  PubMed Two-hybrid 
    BioGRID:117945 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:119018 PACSIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:116413 PACSIN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:118896 PACSIN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:23837 ROP2    BioGRID  PubMed Two-hybrid 
    BioGRID:117945 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117945 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cytoplasmic FMR1-interacting protein 2
    Names
    cytoplasmic FMR1-interacting protein 2
    p53 inducible protein
    p53-inducible protein 121
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037332.2 → NP_001032409.2  cytoplasmic FMR1-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC008676, AL136549, AL559919, BC011762, BG257432
      UniProtKB/Swiss-Prot
      Q96F07
      Related
      ENSP00000313567, ENST00000347377
      Conserved Domains (1) summary
      pfam05994
      Location:384 – 1223
      Blast Score: 3088
      FragX_IP; Cytoplasmic Fragile-X interacting family

    2. NM_001037333.1 → NP_001032410.1  cytoplasmic FMR1-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC008676, AL136549, BC011762
      UniProtKB/Swiss-Prot
      Q96F07
      Related
      ENSP00000430904, OTTHUMP00000224059, ENST00000521420, OTTHUMT00000373710
      Conserved Domains (1) summary
      pfam05994
      Location:384 – 1223
      Blast Score: 3088
      FragX_IP; Cytoplasmic Fragile-X interacting family

    3. NM_014376.2 → NP_055191.2  cytoplasmic FMR1-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different segment for its 5' UTR, compared to variant 2. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC008676, AL136549, BC011762
      UniProtKB/Swiss-Prot
      Q96F07
      Related
      ENSP00000366799, ENST00000377576
      Conserved Domains (1) summary
      pfam05994
      Location:384 – 1223
      Blast Score: 3088
      FragX_IP; Cytoplasmic Fragile-X interacting family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      156693091..156822606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      151780753..151910647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008676.6 (158749..180695) None
    genomic AC009185.6 (43966..87972) None
    genomic AC016571.7 (13002..73303) None
    genomic CH471062.2 EAW61603.1
      EAW61604.1
      EAW61605.1
      EAW61606.1
    mRNA AB032994.2 BAA86482.2
    mRNA AF132197.1 AAG35543.1
    mRNA AF160973.1 AAD45723.1
    mRNA AK172724.1 None
    mRNA AK223604.1 BAD97324.1
    mRNA AK294220.1 BAH11703.1
    mRNA AK295865.1 BAH12208.1
    mRNA AK297401.1 BAH12569.1
    mRNA AK303702.1 BAH14023.1
    mRNA AK312157.1 BAG35091.1
    mRNA AL136549.1 CAB66484.1
    mRNA AL161999.1 CAB82329.1
    mRNA AL559919.3 None
    mRNA BC011762.1 AAH11762.1
    mRNA BC021008.1 None
    mRNA BC026892.2 None
    mRNA BC066933.1 None
    mRNA BG257432.1 None
    mRNA L47738.1 AAA79022.1
    other-genetic AM393359.1 CAL38237.1
    other-genetic AM393421.1 CAL38299.1
    other-genetic DQ893528.2 ABM84454.1
    other-genetic DQ896615.2 ABM87614.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14650 GenPept UniProtKB/TrEMBL:Q14650
    Q96F07.2 GenPept UniProtKB/Swiss-Prot:Q96F07
    Q9H360 GenPept UniProtKB/TrEMBL:Q9H360
    Q9NSN1 GenPept UniProtKB/TrEMBL:Q9NSN1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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