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    HBP1 HMG-box transcription factor 1 [ Homo sapiens ]

    Gene ID: 26959, updated on 11-May-2012
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    Summary

    Official Symbol
    HBP1provided by HGNC
    Official Full Name
    HMG-box transcription factor 1provided by HGNC
    Primary source
    HGNC:23200
    See related
    Ensembl:ENSG00000105856; HPRD:13634; Vega:OTTHUMG00000157642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ16340
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    Genomic context

    Location :
    7q22-q31
    Sequence :
    Chromosome: 7; NC_000007.13 (106809460..106842974)
    See HBP1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase, catalytic, gamma polypeptide Neighboring gene protein kinase, cAMP-dependent, regulatory, type II, beta Neighboring gene uncharacterized LOC100506312 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Wang W, et al. Nucleic Acids Res, 2012 Feb. PMID 21967847.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. Li H, et al. Oncogene, 2010 Sep 9. PMID 20581871.
    5. miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Li H, et al. Breast Cancer Res Treat, 2011 Apr. PMID 20505989.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/beta-catenin
      Title: miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1.
    2. HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence.
      Title: Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence.
    3. HBP1 directly inhibits MIF gene transcription, which is overexpressed in prostatic cancer.
      Title: Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer.
    4. HBP1 binds c-Myc in cells, and expression of HBP1 inhibits c-Myc transactivational activity at least partly by preventing c-Myc binding to target gene promoters.
      Title: The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
    5. EGCG blocks Wnt signaling by inducing the HBP1 transcriptional repressor and inhibits aspects of invasive breast cancer
      Title: Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1.
    6. Transgenic mice overexpressing HBP1 exhibit altered thymus cellularity and decreased thymocyte development.
      Title: Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation.
    7. Results indicate that HBP1 may contribute to the regulation of NADPH oxidase-dependent superoxide production through transcriptional repression of the p47phox gene.
      Title: HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase.
    8. in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation
      Title: Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells.
    9. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations
      Title: HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.
    10. NMR study of the AXH domain
      Title: Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1.
    Submit: New GeneRIF Correction See all (15)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O60381 Q01844 EWSR1    HPRD  PubMed  
    O60381 Q13547 HDAC1    HPRD  PubMed  
    O60381 Q96EK5 KIAA1279    HPRD  PubMed  
    O60381 P06400 RB1    HPRD  PubMed  
    O60381 Q08999 RBL2    HPRD  PubMed  
    O60381 O75446 SAP30    HPRD  PubMed  
    O60381 Q96ST3 SIN3A    HPRD  PubMed  
    O60381 Q15797 SMAD1    HPRD  PubMed  
    O60381 P15884 TCF4    HPRD  PubMed  
    BioGRID:117927 BioGRID:117669 ANKRD2    BioGRID  PubMed Two-hybrid 
    BioGRID:117927 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:117927 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:117927 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117927 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:117927 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117927 BioGRID:111869 RBL2    BioGRID  PubMed Two-hybrid 
    BioGRID:117927 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:117927 BioGRID:112787 TCF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117927 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    HMG box-containing protein 1
    Names
    HMG box-containing protein 1
    HMG box transcription factor 1
    high mobility group box transcription factor 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244262.1 → NP_001231191.1  HMG box-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK295910, BC017069
      UniProtKB/TrEMBL
      B4DJ36
      UniProtKB/Swiss-Prot
      O60381
      Conserved Domains (2) summary
      cd01388
      Location:443 – 514
      Blast Score: 266
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      cl02647
      Location:224 – 350
      Blast Score: 474
      AXH; Ataxin-1 and HBP1 module (AXH)

    2. NM_012257.3 → NP_036389.2  HMG box-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF182038, AK025284, BC017069
      Consensus CDS
      CCDS5741.1
      UniProtKB/Swiss-Prot
      O60381
      Related
      ENSP00000222574, OTTHUMP00000212317, ENST00000222574, OTTHUMT00000349297
      Conserved Domains (2) summary
      cd01388
      Location:433 – 504
      Blast Score: 266
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      cl02647
      Location:214 – 340
      Blast Score: 473
      AXH; Ataxin-1 and HBP1 module (AXH)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      106809460..106842974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      101170009..101203527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      106170547..106204061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004492.1 AAC08317.1
    genomic CH236947.1 (21282397..21315911) None
    genomic CH471070.1 EAW83392.1
      EAW83393.1
      EAW83394.1
    mRNA AF019214.1 AAB71862.1
    mRNA AF182038.1 AAD56225.1
    mRNA AK025284.1 None
    mRNA AK074353.1 BAB85059.1
    mRNA AK122785.1 BAG53729.1
    mRNA AK295910.1 BAG58698.1
    mRNA AK298504.1 BAG60711.1
    mRNA BC017069.1 AAH17069.1
    mRNA BC022329.2 AAH22329.1
    other-genetic DQ891576.2 ABM82502.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14790 GenPept UniProtKB/TrEMBL:O14790
    O60381.2 GenPept UniProtKB/Swiss-Prot:O60381
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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