U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nkain3 Na+/K+ transporting ATPase interacting 3 [ Mus musculus (house mouse) ]

Gene ID: 269513, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Nkain3provided by MGI
Official Full Name
Na+/K+ transporting ATPase interacting 3provided by MGI
Primary source
MGI:MGI:2444830
See related
Ensembl:ENSMUSG00000055761 AllianceGenome:MGI:2444830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C530048M05; E130310K16Rik
Summary
Predicted to be involved in regulation of sodium ion transport. Located in membrane. Is expressed in central nervous system and retina. Orthologous to human NKAIN3 (sodium/potassium transporting ATPase interacting 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 2.5), CNS E18 (RPKM 2.2) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A3; 4 7.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (20111029..20779990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (20111029..20780709, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small cell adhesion glycoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_09708 Neighboring gene STARR-positive B cell enhancer mm9_chr4:20118894-20119195 Neighboring gene gamma-glutamyl hydrolase Neighboring gene STARR-seq mESC enhancer starr_09709 Neighboring gene predicted gene, 52761 Neighboring gene STARR-seq mESC enhancer starr_09710 Neighboring gene predicted gene 11872 Neighboring gene tubulin, alpha 4A pseudogene Neighboring gene STARR-seq mESC enhancer starr_09711 Neighboring gene STARR-seq mESC enhancer starr_09712 Neighboring gene STARR-seq mESC enhancer starr_09713 Neighboring gene STARR-seq mESC enhancer starr_09714 Neighboring gene STARR-seq mESC enhancer starr_09715 Neighboring gene STARR-seq mESC enhancer starr_09716 Neighboring gene STARR-seq mESC enhancer starr_09718 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09719 Neighboring gene STARR-seq mESC enhancer starr_09721 Neighboring gene predicted gene, 25977

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290410.1 → NP_001277339.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001277339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK141456, BC075683, CR931798
    Consensus CDS
    CCDS71349.1
    UniProtKB/Swiss-Prot
    A2ANL4, A6MHP8, A6MHQ0, Q3URJ8, Q6DI91, Q8BPL2, Q8C7P6
    Related
    ENSMUSP00000113113.2, ENSMUST00000119374.8
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 177
    NKAIN; Na,K-Atpase Interacting protein

  2. NM_172987.2 → NP_766575.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_766575.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC075683
    Consensus CDS
    CCDS17997.1
    UniProtKB/Swiss-Prot
    Q3URJ8
    Related
    ENSMUSP00000100063.4, ENSMUST00000102998.4
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 158
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    20111029..20779990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537951.5 → XP_006538014.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X1

    Conserved Domains (1) summary
    pfam05640
    Location:10 → 198
    NKAIN; Na,K-Atpase Interacting protein

  2. XM_011250046.4 → XP_011248348.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X2

    Conserved Domains (1) summary
    pfam05640
    Location:10 → 198
    NKAIN; Na,K-Atpase Interacting protein

  3. XM_011250047.3 → XP_011248349.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:10 → 159
    NKAIN; Na,K-Atpase Interacting protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URJ8.1 GenPept UniProtKB/Swiss-Prot:Q3URJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous