Format

Send to:

Choose Destination

Setx senataxin [ Mus musculus (house mouse) ]

Gene ID: 269254, updated on 28-May-2016
Official Symbol
Setxprovided by MGI
Official Full Name
senataxinprovided by MGI
Primary source
MGI:MGI:2443480
See related
Ensembl:ENSMUSG00000043535 Vega:OTTMUSG00000011825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AOA2; Als4; Sen1; SCAR1; AW060766; mKIAA0625; A130090N03; A930037J23Rik
Orthologs
Location:
2; 2 A3
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (29122588..29182471)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (28980512..29037991)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene transcription termination factor, RNA polymerase I Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene RIKEN cDNA 6530402F18 gene Neighboring gene netrin G2 Neighboring gene mediator complex subunit 27 Neighboring gene microRNA 133c

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription termination site sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA-templated transcription, termination ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mRNA splice site selection ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-templated transcription, initiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-templated transcription, termination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase II transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
probable helicase senataxin
Names
SEN1 homolog
amyotrophic lateral sclerosis 4 homolog
amyotrophic lateral sclerosis 4 protein homolog
NP_932150.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198033.2NP_932150.2  probable helicase senataxin

    See identical proteins and their annotated locations for NP_932150.2

    Status: VALIDATED

    Source sequence(s)
    AL772379, AL845267, BC058109, BK001523
    Consensus CDS
    CCDS38090.1
    UniProtKB/Swiss-Prot
    A2AKX3
    Related
    ENSMUSP00000051492, OTTMUSP00000012614, ENSMUST00000061578, OTTMUST00000027763
    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012400
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    29122588..29182471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239105.1XP_011237407.1  

    See identical proteins and their annotated locations for XP_011237407.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
  2. XM_011239106.1XP_011237408.1  

    See identical proteins and their annotated locations for XP_011237408.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
  3. XM_011239107.1XP_011237409.1  

    See identical proteins and their annotated locations for XP_011237409.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
  4. XM_006498080.2XP_006498143.1  

    See identical proteins and their annotated locations for XP_006498143.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
  5. XM_006498079.2XP_006498142.1  

    See identical proteins and their annotated locations for XP_006498142.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
  6. XM_006498084.2XP_006498147.1  

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain
    cl22977
    Location:22012255
    UvrD_C_2; UvrD-like helicase C-terminal domain
  7. XM_006498082.2XP_006498145.1  

    See identical proteins and their annotated locations for XP_006498145.1

    Conserved Domains (4) summary
    pfam12726
    Location:34351
    SEN1_N; SEN1 N terminal
    pfam13086
    Location:19102193
    AAA_11; AAA domain
    pfam13087
    Location:22012455
    AAA_12; AAA domain
    pfam13245
    Location:19331996
    AAA_19; Part of AAA domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    28830977..28888543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)