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Med14 mediator complex subunit 14 [ Mus musculus (house mouse) ]

Gene ID: 26896, updated on 11-Apr-2024

Summary

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Official Symbol
Med14provided by MGI
Official Full Name
mediator complex subunit 14provided by MGI
Primary source
MGI:MGI:1349442
See related
Ensembl:ENSMUSG00000064127 AllianceGenome:MGI:1349442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF1; Crsp2; Gm641; Trap170; 9930001L01Rik
Summary
Predicted to enable transcription coactivator activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 7.52 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (12541607..12628813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (12675368..12762594, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810030O07 gene Neighboring gene STARR-seq mESC enhancer starr_46759 Neighboring gene predicted pseudogene 4984 Neighboring gene predicted gene, 52422 Neighboring gene STARR-seq mESC enhancer starr_46762 Neighboring gene predicted gene 14634 Neighboring gene STARR-seq mESC enhancer starr_46765 Neighboring gene STARR-seq mESC enhancer starr_46768 Neighboring gene STARR-seq mESC enhancer starr_46771 Neighboring gene STARR-seq mESC enhancer starr_46772 Neighboring gene expressed sequence AA414768 Neighboring gene peptidylprolyl isomerase A pseudogene x_132.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method. Takada S, et al. Genomics, 1999 Oct 1. PMID 10512684
  2. MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Grøntved L, et al. Mol Cell Biol, 2010 May. PMID 20194623, Free PMC Article
  3. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
  4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
  5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes.
    Title: MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 14
Names
CRSP complex subunit 2
cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)
cofactor required for Sp1 transcriptional activation, subunit 2
thyroid hormone receptor-associated protein complex 170 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048208.1 → NP_001041673.1  mediator of RNA polymerase II transcription subunit 14 isoform a

    See identical proteins and their annotated locations for NP_001041673.1

    Status: VALIDATED

    Source sequence(s)
    BC065072, BX000537, CN724751
    Consensus CDS
    CCDS40874.1
    UniProtKB/Swiss-Prot
    A2ABV5, Q3TQU3, Q6P1H5, Q9R0T1, Q9WTN9
    Related
    ENSMUSP00000094239.5, ENSMUST00000096495.11
    Conserved Domains (2) summary
    pfam03957
    Location:1052 → 1147
    Jun; Jun-like transcription factor
    pfam08638
    Location:57 → 244
    Med14; Mediator complex subunit MED14

  2. NM_012005.3 → NP_036135.3  mediator of RNA polymerase II transcription subunit 14 isoform b

    Status: VALIDATED

    Source sequence(s)
    BC065072, BX631997, CN724751
    UniProtKB/Swiss-Prot
    A2ABV5
    Related
    ENSMUST00000124053.2
    Conserved Domains (2) summary
    pfam03957
    Location:1052 → 1147
    Jun; Jun-like transcription factor
    pfam08638
    Location:57 → 244
    Med14; Mediator complex subunit MED14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    12541607..12628813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527629.5 → XP_006527692.1  mediator of RNA polymerase II transcription subunit 14 isoform X1

    Conserved Domains (2) summary
    pfam15822
    Location:1023 → 1157
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    pfam08638
    Location:57 → 242
    Med14; Mediator complex subunit MED14

  2. XM_006527630.5 → XP_006527693.1  mediator of RNA polymerase II transcription subunit 14 isoform X2

    Conserved Domains (1) summary
    pfam08638
    Location:57 → 242
    Med14; Mediator complex subunit MED14

RNA

  1. XR_878029.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ABV5.1 GenPept UniProtKB/Swiss-Prot:A2ABV5

Gene LinkOut

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