Fbxo45 F-box protein 45 [Mus musculus] - Gene

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Summary

Official Symbol: Fbxo45provided by MGI
Official Full Name: F-box protein 45provided by MGI
Primary source: MGI:2447775
See related: Ensembl:ENSMUSG00000035764; Vega:OTTMUSG00000025766
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI463119; BC026799; 2610017J04Rik; MGC19444; MGC90920

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Genomic context

Location :: 16 B2; 16

Sequence :: Chromosome: 16; NC_000082.6 (32230112..32247025, complement)

See Fbxo45 in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Fbxo45 plays an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse.
Title: Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
Results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development.
Title: Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:234572	BioGRID:112391	SKP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:234572	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:234572	BioGRID:116665	UNC13A	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info
proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	ISO Inferred from Sequence Orthology more info
protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
postsynaptic membrane	IEA Inferred from Electronic Annotation more info
synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: F-box/SPRY domain-containing protein 1

Names: F-box/SPRY domain-containing protein 1; mFbxo45; F-box only protein 45

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173439.2 → NP_775615.2 F-box/SPRY domain-containing protein 1

Status: PROVISIONAL

Source sequence(s)

BC088738

Consensus CDS

CCDS28117.1

UniProtKB/Swiss-Prot

Q8K3B1

Related

ENSMUSP00000040168, OTTMUSP00000031376, ENSMUST00000042732, OTTMUST00000063466

Conserved Domains (2) summary

cl02535
Location:38 – 85
Blast Score: 134

F-box; F-box domain

cl02614
Location:153 – 283
Blast Score: 185

SPRY; SPRY domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38 C57BL/6J

Range

32230112..32247025, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

32715107..32732068, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC126265.3 (104881..121794)	None
genomic	CH466521.1	EDK97777.1	mixed
mRNA	AK011438.1	None	C57BL/6J
mRNA	BC026799.1	AAH26799.1	FVB/N
mRNA	BC088738.1	AAH88738.1
mRNA	BC098203.1	AAH98203.1	C57BL/6