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Shprh SNF2 histone linker PHD RING helicase [ Mus musculus (house mouse) ]

Gene ID: 268281, updated on 28-May-2016
Official Symbol
Shprhprovided by MGI
Official Full Name
SNF2 histone linker PHD RING helicaseprovided by MGI
Primary source
MGI:MGI:1917581
See related
Ensembl:ENSMUSG00000090112 Vega:OTTMUSG00000034163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA450458; AU024614; BC006883; E130018M05; 2610103K11Rik; D230017O13Rik
Orthologs
Location:
10; 10 A1
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (11149321..11217595)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (10869228..10935072)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RIKEN cDNA 4930567K20 gene Neighboring gene glutamate receptor, metabotropic 1 Neighboring gene leucine-rich repeat extensin-like protein 5 Neighboring gene F-box protein 30 Neighboring gene ribosomal protein L17, pseudogene 11 Neighboring gene epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase SHPRH
Names
SNF2, histone-linker, PHD and RING finger domain-containing helicase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077707.1NP_001071175.1  E3 ubiquitin-protein ligase SHPRH isoform a

    See identical proteins and their annotated locations for NP_001071175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK082160, BB650602, BC055003, BP757728
    Consensus CDS
    CCDS35838.1
    UniProtKB/Swiss-Prot
    Q7TPQ3
    Related
    ENSMUSP00000039422, OTTMUSP00000046890, ENSMUST00000044053, OTTMUST00000086593
    Conserved Domains (6) summary
    COG0553
    Location:13141669
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00073
    Location:435507
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cd00079
    Location:15021620
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00162
    Location:14231473
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00176
    Location:706978
    SNF2_N; SNF2 family N-terminal domain
    cd15547
    Location:651697
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
  2. NM_001284354.1NP_001271283.1  E3 ubiquitin-protein ligase SHPRH isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform c which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK044720, AK053448, BB650602, BC055003
    Consensus CDS
    CCDS70003.1
    UniProtKB/Swiss-Prot
    Q7TPQ3
    Related
    ENSMUSP00000132870, OTTMUSP00000051850, ENSMUST00000159541, OTTMUST00000086597
    Conserved Domains (6) summary
    COG0553
    Location:13141619
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00073
    Location:435507
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cd00079
    Location:15021616
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00162
    Location:14231473
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00176
    Location:706978
    SNF2_N; SNF2 family N-terminal domain
    cd15547
    Location:651697
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
  3. NM_172937.3NP_766525.3  E3 ubiquitin-protein ligase SHPRH isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a distinct 3' UTR compared to variant 1. It encodes isoform b which is truncated at the C-terminus, compared to isoform a.
    Source sequence(s)
    AC158601, AK044720, AK082160, BB650602, BC055003
    Consensus CDS
    CCDS35839.1
    UniProtKB/Swiss-Prot
    Q7TPQ3
    Related
    ENSMUSP00000125849, OTTMUSP00000051849, ENSMUST00000054814, OTTMUST00000086596
    Conserved Domains (6) summary
    COG0553
    Location:13141616
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00073
    Location:435507
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cd00079
    Location:15021616
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00162
    Location:14231473
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00176
    Location:706978
    SNF2_N; SNF2 family N-terminal domain
    cd15547
    Location:651697
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    11149321..11217595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512740.2XP_006512803.1  

    See identical proteins and their annotated locations for XP_006512803.1

    UniProtKB/Swiss-Prot
    Q7TPQ3
    Conserved Domains (6) summary
    COG0553
    Location:13141669
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00073
    Location:435507
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cd00079
    Location:15021620
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00162
    Location:14231473
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00176
    Location:706978
    SNF2_N; SNF2 family N-terminal domain
    cd15547
    Location:651697
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH

RNA

  1. XR_380065.2 RNA Sequence

    Related
    ENSMUST00000159810, OTTMUST00000086594
  2. XR_871438.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    11042359..11108579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)