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    RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 [ Homo sapiens ]

    Gene ID: 26750, updated on 11-May-2012
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    Summary

    Official Symbol
    RPS6KC1provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase, 52kDa, polypeptide 1provided by HGNC
    Primary source
    HGNC:10439
    See related
    Ensembl:ENSG00000136643; HPRD:10204; Vega:OTTHUMG00000036926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPK118; humS6PKh1
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    Genomic context

    Location :
    1q41
    Sequence :
    Chromosome: 1; NC_000001.10 (213224588..213446808)
    See RPS6KC1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene vasohibin 2 Neighboring gene angel homolog 2 (Drosophila) Neighboring gene ribosomal protein L31 pseudogene 13 Neighboring gene PROX1 antisense RNA 1 (non-protein coding)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. cloning and characterization of RPK118 as a sphingosine kinase-1-binding protein
      Title: Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.
    2. findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking.
      Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_036556.2 NP_006784.1 PRDX3    BIND  PubMed RPK118 interacts with PRDX3. 
    Q96S38 P40425 PBX2    HPRD  PubMed  
    Q96S38 P30048 PRDX3    HPRD  PubMed  
    Q96S38 Q96S38 RPS6KC1    HPRD  PubMed  
    Q96S38 Q9NYA1 SPHK1    HPRD  PubMed  
    BioGRID:117810 BioGRID:114396 SPHK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117810 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ribosomal protein S6 kinase delta-1
    Names
    ribosomal protein S6 kinase delta-1
    S6K-delta-1
    SPHK1-binding protein
    52 kDa ribosomal protein S6 kinase
    ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
    NP_001129610.1
    NP_036556.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136138.1 → NP_001129610.1  ribosomal protein S6 kinase delta-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AF477978, DB060692
      Consensus CDS
      CCDS44317.1
      UniProtKB/TrEMBL
      B1APS8
      UniProtKB/Swiss-Prot
      Q96S38
      Related
      ENSP00000355926, OTTHUMP00000035019, ENST00000366959, OTTHUMT00000089691
      Conserved Domains (4) summary
      cd02677
      Location:251 – 300
      Blast Score: 184
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:883 – 1044
      Blast Score: 883
      STKc_RPK118_like; Catalytic domain of the Protein Serine/Threonine Kinases, RPK118 and similar proteins
      cl02563
      Location:11 – 116
      Blast Score: 571
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl09925
      Location:329 – 414
      Blast Score: 433
      PKc_like; Protein Kinases, catalytic domain

    2. NM_012424.3 → NP_036556.2  ribosomal protein S6 kinase delta-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AF477978, DB060692
      Consensus CDS
      CCDS1513.1
      UniProtKB/Swiss-Prot
      Q96S38
      Related
      ENSP00000355927, OTTHUMP00000035018, ENST00000366960, OTTHUMT00000089690
      Conserved Domains (4) summary
      cd02677
      Location:263 – 312
      Blast Score: 183
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd07287
      Location:11 – 128
      Blast Score: 657
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd05576
      Location:895 – 1056
      Blast Score: 883
      STKc_RPK118_like; Catalytic domain of the Protein Serine/Threonine Kinases, RPK118 and similar proteins
      cl09925
      Location:341 – 426
      Blast Score: 433
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      213224588..213446808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      183899388..184120831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL512449.6 CAH71999.1
      CAH72000.1
    genomic AL583826.16 CAH73804.1
      CAH73805.1
    genomic AL645860.5 CAH70703.1
      CAH70704.1
    genomic CH471100.2 EAW93362.1
      EAW93363.1
      EAW93364.1
    mRNA AB070706.1 BAB63956.1
    mRNA AF037447.1 AAF13027.1
    mRNA AF477978.1 AAL84818.1
    mRNA AK122921.1 None
    mRNA AK122989.1 BAG53836.1
    mRNA AK295053.1 BAG58102.1
    mRNA AK299298.1 BAG61312.1
    mRNA AL356893.1 CAB92850.1
    mRNA BC104769.1 AAI04770.1
    mRNA BC143449.1 None
    mRNA BC143473.1 None
    mRNA BC143474.1 None
    mRNA BX647303.1 None
    mRNA DB060692.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S38.2 GenPept UniProtKB/Swiss-Prot:Q96S38
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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