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    AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 267, updated on 11-May-2012

    Summary

    Official Symbol
    AMFRprovided by HGNC
    Official Full Name
    autocrine motility factor receptor, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:463
    See related
    Ensembl:ENSG00000159461; HPRD:09130; MIM:603243; Vega:OTTHUMG00000133239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP78; RNF45
    Summary
    This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

    Genomic context

    Location :
    16q21
    Sequence :
    Chromosome: 16; NC_000016.9 (56395364..56459444, complement)
    See AMFR in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Neighboring gene microRNA 3935 Neighboring gene uncharacterized LOC100505722 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 21 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UKV5 P06744 GPI    HPRD  PubMed  
    Q9UKV5 P62837 UBE2D2    HPRD  PubMed  
    Q9UKV5 P60604 UBE2G2    HPRD  PubMed  
    Q9UKV5 P55072 VCP    HPRD  PubMed  
    BioGRID:106764 BioGRID:114579 AIFM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:106978 ATP2A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:110433 ATXN3    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:106764 BioGRID:107271 CANX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:121318 CCDC47    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:107353 CD3D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:107821 CSE1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:107944 CYP2E1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106764 BioGRID:107948 CYP3A4    BioGRID  PubMed Biochemical Activity 
    BioGRID:106764 BioGRID:122559 DERL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:119216 DERL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:124816 DERL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:115859 ERLIN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106764 BioGRID:116331 ERLIN2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106764 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106764 BioGRID:115719 HAX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:115060 HERPUD1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106764 BioGRID:109399 HMGCR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:109314 HTT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:109850 INSIG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:122240 PDIA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:120576 RHOT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:111975 RNF5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:112045 RPL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:116152 SEC61B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:120934 SELS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106764 BioGRID:112530 SOD1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:106764 BioGRID:121810 SRPRB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:129222 SVIP    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:106764 BioGRID:124085 SYVN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:124961 TIMM50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:123686 TMUB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106764 BioGRID:115352 TOM1L1    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106764 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:113170 UBE2D2    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:106764 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:113174 UBE2G1    BioGRID  PubMed Co-crystal Structure 
    BioGRID:106764 BioGRID:113175 UBE2G2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:118858 UBE2T    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:106764 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106764 BioGRID:113200 UFD1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106764 BioGRID:204416 Ube2g2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:106764 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ER-associated protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER-associated protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    cellular component movement TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    protein oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    integral to endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral to membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral to membrane of membrane fraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    autocrine motility factor receptor
    Names
    autocrine motility factor receptor
    RING finger protein 45
    NP_001135.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144.5NP_001135.3  autocrine motility factor receptor

      Status: REVIEWED

      Source sequence(s)
      AA767223, AC009102, BC069197, BX345849, BX409690, CA748782
      Consensus CDS
      CCDS10758.1
      UniProtKB/Swiss-Prot
      Q9UKV5
      Related
      ENSP00000290649, OTTHUMP00000164316, ENST00000290649, OTTHUMT00000256978
      Conserved Domains (3) summary
      cd00162
      Location:340382
      Blast Score: 133
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      COG5243
      Location:86382
      Blast Score: 262
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cl02655
      Location:456497
      Blast Score: 120
      CUE; CUE domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      56395364..56459444, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      42266003..42329606, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138958.1: Suppressed sequence

      Description
      NM_138958.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009102.10 None
    genomic AC092140.4 (91020..118920) None
    genomic CQ834404.1 CAH05417.1
    mRNA AA767223.1 None
    mRNA AF124145.1 AAD56722.1
    mRNA AK023874.1 None
    mRNA BC017043.1 AAH17043.1
    mRNA BC051032.1 None
    mRNA BC056869.1 AAH56869.1
    mRNA BC069197.1 AAH69197.1
    mRNA BX345849.2 None
    mRNA BX409690.2 None
    mRNA CA748782.1 None
    mRNA L35233.1 AAA79362.1
    mRNA M63175.1 AAA36671.1
    mRNA W60999.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26442.1 GenPept UniProtKB/Swiss-Prot:P26442
    Q1RN03 GenPept UniProtKB/TrEMBL:Q1RN03
    Q6PGR1 GenPept UniProtKB/TrEMBL:Q6PGR1
    Q9UKV5.2 GenPept UniProtKB/Swiss-Prot:Q9UKV5

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