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Cul3 cullin 3 [ Mus musculus (house mouse) ]

Gene ID: 26554, updated on 21-May-2016
Official Symbol
Cul3provided by MGI
Official Full Name
cullin 3provided by MGI
Primary source
MGI:MGI:1347360
See related
Ensembl:ENSMUSG00000004364 Vega:OTTMUSG00000035349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIAA0617
Orthologs
Location:
1; 1 C4
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (80265610..80340762, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (80263393..80337005, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 124, member B Neighboring gene RIKEN cDNA 2310015K22 gene Neighboring gene predicted gene, 34098 Neighboring gene predicted gene, 39667 Neighboring gene GLE1 RNA export mediator pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
POZ domain binding ISO
Inferred from Sequence Orthology
more info
 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
 
ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cellular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
polar microtubule ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313728.1NP_001300657.1  cullin-3 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC161416, AC166157, AF129738, AK003885, AK034695, BE991461, BM899470, CK634506
    UniProtKB/Swiss-Prot
    Q9JLV5
    UniProtKB/TrEMBL
    Q9CTE0
    Conserved Domains (3) summary
    smart00182
    Location:370512
    CULLIN; Cullin
    pfam00888
    Location:38615
    Cullin; Cullin family
    pfam10557
    Location:644710
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_016716.5NP_057925.1  cullin-3 isoform 1

    See identical proteins and their annotated locations for NP_057925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161416, AF129738, AK003885, AK034695, BE991461, BM899470
    Consensus CDS
    CCDS15094.1
    UniProtKB/Swiss-Prot
    Q9JLV5
    UniProtKB/TrEMBL
    Q9CTE0
    Related
    ENSMUSP00000130738, OTTMUSP00000049459, ENSMUST00000163119, OTTMUST00000090232
    Conserved Domains (3) summary
    smart00182
    Location:421563
    CULLIN; Cullin
    pfam00888
    Location:34666
    Cullin; Cullin family
    pfam10557
    Location:695761
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    80265610..80340762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496495.2XP_006496558.1  

    Conserved Domains (3) summary
    smart00182
    Location:370512
    CULLIN; Cullin
    pfam00888
    Location:38615
    Cullin; Cullin family
    pfam10557
    Location:644710
    Cullin_Nedd8; Cullin protein neddylation domain
  2. XM_006496498.2XP_006496561.1  

    Conserved Domains (3) summary
    smart00182
    Location:340482
    CULLIN; Cullin
    pfam00888
    Location:6585
    Cullin; Cullin family
    pfam10557
    Location:614680
    Cullin_Nedd8; Cullin protein neddylation domain
  3. XM_006496497.2XP_006496560.1  

    Conserved Domains (3) summary
    smart00182
    Location:343485
    CULLIN; Cullin
    pfam00888
    Location:10588
    Cullin; Cullin family
    pfam10557
    Location:617683
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    80291823..80365420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)