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    KAT2A K(lysine) acetyltransferase 2A [ Homo sapiens ]

    Gene ID: 2648, updated on 19-May-2012
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    Summary

    Official Symbol
    KAT2Aprovided by HGNC
    Official Full Name
    K(lysine) acetyltransferase 2Aprovided by HGNC
    Primary source
    HGNC:4201
    See related
    Ensembl:ENSG00000108773; HPRD:03807; MIM:602301; Vega:OTTHUMG00000133504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCN5; hGCN5; GCN5L2; PCAF-b; MGC102791
    Summary
    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
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    Genomic context

    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (40265129..40273382, complement)
    See KAT2A in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507656 Neighboring gene DEXH (Asp-Glu-X-His) box polypeptide 58 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Krebs AR, et al. Mol Cell, 2011 Nov 4. PMID 22055187.
    2. The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase. Li Y, et al. J Biol Chem, 2011 Dec 2. PMID 21987584.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. And-1 is required for the stability of histone acetyltransferase Gcn5. Li Y, et al. Oncogene, 2012 Feb 2. PMID 21725360.
    5. Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells. Choudhury M, et al. Alcohol, 2011 Jun. PMID 21367571.

    See all (76) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that And-1 forms a complex with both histone H3 and Gcn5.
      Title: And-1 is required for the stability of histone acetyltransferase Gcn5.
    2. Human HAT complexes, sharing the same catalytic GCN5 or PCAF subunit are targeted to different genomic loci representing functionally distinct regulatory elements.
      Title: SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.
    3. GCN5 differentially affects expression of multiple genes; ethanol-induced histone H3-lysine 9 acetylation is mediated via GCN5, and GCN5 is involved in ethanol-induced expression of the putative choline transporter SLC44A2.
      Title: Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells.
    4. Deletion of GCN5/PCAF in cells specifically and dramatically reduces acetylation on histone H3K9.
      Title: Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
    5. Data show that Pygo2 associates with MLL2 histone methyltransferase and STAGA histone acetyltransferase to facilitate their interaction with beta-catenin and Wnt1-induced, TCF/LEF-dependent transactivation in breast cancer cells.
      Title: Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.
    6. In this study the authors demonstrate that another cellular histone acetyltransferase, GCN5, acetylates HIV-1 integrase leading to enhanced 3'-end processing and strand transfer activities.
      Title: GCN5-dependent acetylation of HIV-1 integrase enhances viral integration.
    7. PGC-1beta is a substrate for general control of amino-acid synthesis (GCN5) and is acetylated on at least 10 lysine residues that are distributed along multiple domains of the protein.
      Title: GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.
    8. Gcn5 regulates TRF1 levels through effects on Usp22 activity and SAGA integrity.
      Title: Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.
    9. Knockdown of p300 reduces acetylation of Atg5, Atg7, Atg8, and Atg12, although overexpressed p300 increases the acetylation of these same proteins.
      Title: Regulation of autophagy by the p300 acetyltransferase.
    10. GCN5, a histone acetyltransferase, associates with COMMD1 and other components of the ligase, promotes RelA ubiquitination, and represses kappaB-dependent transcription
      Title: GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
    Submit: New GeneRIF Correction See all (23)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Binding of HIV-1 Tat to hGCN5 is mediated by amino acids 20-48 of Tat (includes cysteine rich, core, and minimal activation domains of Tat) and by amino acids 111-151 (histone acetyltransferase domain) and 389-476 (bromodomain) of hGCN5 PubMed
    tat hGCN5 enhances HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat is acetylated by hGCN5 on lysines 50 and 51 PubMed
    tat HIV-1 Tat inhibits the histone acetyltransferase and transcriptional activation activities of hGCN5, an effect mediated by amino acids 86-101 of Tat PubMed
    tat HIV-1 Tat recruits hGCN5, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_066564.1 NP_002458.1 MYC    BIND  PubMed c-Myc interacts with GNC5L. 
    NP_066564.1 NP_006274.1 TACC1    BIND  PubMed TACC1 interacts with hGCN5L2. 
    NP_066564.1 NP_996743.1 TACC2    BIND  PubMed TACC2 interacts with hGCN5L2. 
    NP_066564.1 NP_006333.1 TACC3    BIND  PubMed TACC3 interacts with hGCN5L2. 
    Q92830 O15265 ATXN7    HPRD  PubMed  
    Q92830 Q92793 CREBBP    HPRD  PubMed  
    Q92830 Q09472 EP300    HPRD  PubMed  
    Q92830 Q92985 IRF7    HPRD  PubMed  
    Q92830 P01106 MYC    HPRD  PubMed  
    Q92830 P46531 NOTCH1    HPRD  PubMed  
    Q92830 Q8IXJ6 SIRT2    HPRD  PubMed  
    Q92830 O75410 TACC1    HPRD  PubMed  
    Q92830 O95359 TACC2    HPRD  PubMed  
    Q92830 Q9Y6A5 TACC3    HPRD  PubMed  
    Q92830 O75478 TADA2A    HPRD  PubMed  
    Q92830 Q9Y4A5 TRRAP    HPRD  PubMed  
    Q92830 P12956 XRCC6    HPRD  PubMed  
    BioGRID:108918 BioGRID:106601 ACTL6A    BioGRID  PubMed Co-fractionation 
    BioGRID:108918 BioGRID:32503 ADA2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108918 BioGRID:125231 ADAT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:112221 ATXN7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:121289 ATXN7L3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108918 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108918 BioGRID:127317 COMMD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:107796 CRX    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108918 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:119582 DTL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:117243 EID1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:121267 ENY2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108918 BioGRID:108894 GATA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108918 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:113946 HIST1H3A    BioGRID  PubMed Biochemical Activity 
    BioGRID:108918 BioGRID:113955 HIST1H4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:108918 BioGRID:109524 HSD11B2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108918 BioGRID:109867 IRF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:109868 IRF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:110047 KRT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:110131 LDHA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:116774 MAPK8IP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:115342 MED16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108918 BioGRID:201635 Myc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:201808 Notch1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108918 BioGRID:111127 PCBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:111577 PRKDC    BioGRID  PubMed Biochemical Activity 
    BioGRID:108918 BioGRID:124760 PYGO2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:115417 RAD50    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:109736 RBPJ    BioGRID  PubMed Two-hybrid 
    BioGRID:108918 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108918 BioGRID:117016 SF3B3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:110261 SMAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110265 SMAD5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:110268 SMAD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:114042 SUPT3H    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108918 BioGRID:115242 SUPT7L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:112730 TACC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:115830 TACC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108918 BioGRID:115723 TACC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108918 BioGRID:125555 TADA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108918 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:108918 BioGRID:123775 TAF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:112737 TAF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:117998 TAF5L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108918 BioGRID:112743 TAF9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108918 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:108918 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108918 BioGRID:116914 USP22    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108918 BioGRID:116340 WDHD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108918 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:108918 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the KAT2A gene: The KAT2A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, , A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
      C-MYC pathway, organism-specific biosystem
      C-MYC pathway
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch-HLH transcription pathway, organism-specific biosystem (from REACTOME)
      Notch-HLH transcription pathway, organism-specific biosystemTHE NOTCH-HLH TRANSCRIPTION PATHWAY: Notch signaling was first identified in Drosophila, where it has been studied in detail at the genetic, molecular, biochemical and cellular levels (reviewed in ...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetyltransferase activity (H4-K12 specific) IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H3-K14 acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    metencephalon development IEA
    Inferred from Electronic Annotation
    more info
    		  
    midbrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    telencephalon development IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    histone acetyltransferase KAT2A
    Names
    histone acetyltransferase KAT2A
    STAF97
    hsGCN5
    lysine acetyltransferase 2A
    histone acetyltransferase GCN5
    general control of amino acid synthesis protein 5-like 2
    General control of amino acid synthesis, yeast, homolog-like 2
    GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
    NP_066564.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021078.2 → NP_066564.2  histone acetyltransferase KAT2A

      Status: VALIDATED

      Source sequence(s)
      BC105977, DB497139
      Consensus CDS
      CCDS11417.1
      UniProtKB/Swiss-Prot
      Q92830
      Related
      ENSP00000225916, OTTHUMP00000164769, ENST00000225916, OTTHUMT00000257458
      Conserved Domains (4) summary
      COG5076
      Location:492 – 832
      Blast Score: 325
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd05509
      Location:732 – 831
      Blast Score: 453
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam06466
      Location:94 – 337
      Blast Score: 1248
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
      cl00357
      Location:555 – 627
      Blast Score: 141
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      40265129..40273382, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571052.1 Reference GRCh37.p5 PATCHES

      Range
      399753..408006, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      36030209..36038464, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC105024.8 (134880..143095) None
    genomic CH471152.1 EAW60801.1
      EAW60802.1
      EAW60803.1
    genomic U57316.1 AAC50641.1
    mRNA AF029777.1 AAC39769.1
    mRNA BC032743.1 AAH32743.1
    mRNA BC039907.1 AAH39907.1
    mRNA BC105977.1 AAI05978.1
    mRNA DB497139.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92830.3 GenPept UniProtKB/Swiss-Prot:Q92830
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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