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    Poli polymerase (DNA directed), iota [ Mus musculus ]

    Gene ID: 26447, updated on 11-May-2012
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    Summary

    Official Symbol
    Poliprovided by MGI
    Official Full Name
    polymerase (DNA directed), iotaprovided by MGI
    Primary source
    MGI:1347081
    See related
    Ensembl:ENSMUSG00000038425; Vega:OTTMUSG00000027289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rad30b
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    Genomic context

    Location :
    18 E2; 18 44.0 cM
    Sequence :
    Chromosome: 18; NC_000084.6 (70508680..70530321, complement)
    See Poli in Epigenomics, MapViewer

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930503L19 gene Neighboring gene StAR-related lipid transfer (START) domain containing 6 Neighboring gene methyl-CpG binding domain protein 2 Neighboring gene 60S ribosomal protein L5 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells. Yuan B, et al. J Biol Chem, 2011 May 20. PMID 21454642.
    2. Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin. Burschowsky D, et al. J Biol Chem, 2011 Jan 14. PMID 20929865.
    3. Effect of human cell malignancy on activity of DNA polymerase iota. Kazakov AA, et al. Biochemistry (Mosc), 2010 Jul. PMID 20673215.
    4. Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Dumstorf CA, et al. Proc Natl Acad Sci U S A, 2006 Nov 28. PMID 17114294.
    5. UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Ohkumo T, et al. Mol Cell Biol, 2006 Oct. PMID 17015482.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. in mammalian cells, both polymerases kappa and iota are necessary for the error-free bypass of N(2)-CEdG and N(2)-CMdG.
      Title: The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells.
    2. Upon DNA damage, the UBDs (UBM domains) of polymerase iota (Pol iota) interact with ubiquitinated proliferating cell nuclear antigen to regulate the interchange between processive DNA polymerases and translesional synthesis
      Title: Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.
    3. In the presence of Mg2+, the enzyme was active only in testicles and brain, whereas in the presence of Mn2+ the activity was found in all organs.
      Title: Effect of human cell malignancy on activity of DNA polymerase iota.
    4. Pol iota gene may participate in error-free repair of damaged DNA and prevention of lung tumor development
      Title: Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.
    5. Data suggest that either DNA polymerase iota does not participate in hypermutation, or its role is nonessential and can be readily assumed by another low-fidelity polymerase.
      Title: 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.
    6. identification of two previously unknown ubiquitin-binding domains in the Y-family translesion synthesis polymerases that enable them to interact with monoubiquitinated targets and undergo monoubiquitination in vivo
      Title: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
    7. suggest the involvement of the Pol eta and Pol iota proteins in UV-induced skin carcinogenesis
      Title: UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
    8. Pol kappa and Pol iota double-deficient mice had the normal somatic hypermutation frequency
      Title: Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice.
    9. Although pol iota deficiency alone had no effect, UV-induced skin tumors in pol eta-deficient mice developed 4 weeks earlier in mice concomitantly deficient in pol iota
      Title: Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.
    10. Nucleotide polymorphisms in DNA polymerase iota is associated with lung tumorigenesis in mouse and humans
      Title: Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.
    Submit: New GeneRIF Correction
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_036102.1 NP_062516.2 Rev1    BIND  PubMed Rev1 interacts with Pol-iota. 
    BioGRID:204998 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:204998 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    intracellular ISO
    Inferred from Sequence Orthology
    more info
    		  
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    DNA polymerase iota
    Names
    DNA polymerase iota
    RAD30 homolog B
    NP_001129562.1
    NP_036102.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136090.1 → NP_001129562.1  DNA polymerase iota isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      BC082278
      Consensus CDS
      CCDS50317.1
      UniProtKB/Swiss-Prot
      Q6R3M4
      Related
      ENSMUSP00000124877, OTTMUSP00000048816, ENSMUST00000161542, OTTMUST00000089337
      Conserved Domains (1) summary
      cd01703
      Location:1 – 368
      Blast Score: 1166
      PolY_Pol_iota; DNA Polymerase iota

    2. NM_011972.2 → NP_036102.2  DNA polymerase iota isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134831
      Consensus CDS
      CCDS29334.2
      UniProtKB/TrEMBL
      E9QJU6
      Related
      ENSMUSP00000039869, ENSMUST00000043286
      Conserved Domains (1) summary
      cd01703
      Location:51 – 431
      Blast Score: 1241
      PolY_Pol_iota; DNA Polymerase iota

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38 C57BL/6J

      Range
      70508680..70530321, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      71794609..71816285, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC134831.3 (109270..130911) None
    genomic AF489425.1 AAP97325.1 129/Sv
    genomic CH466528.2 EDL09567.1 mixed
      EDL09568.1 mixed
      EDL09569.1 mixed
      EDL09570.1 mixed
      EDL09571.1 mixed
    mRNA AF151691.1 AAD50424.1 BALB/c
    mRNA AK006905.1 BAC25154.1 C57BL/6J
    mRNA AK145244.1 BAE26322.1
    mRNA AK154537.1 BAE32662.1 NOD
    mRNA AK163784.1 BAE37492.1 C57BL/6J
    mRNA AY515316.1 AAS75834.1 A/J
    mRNA AY515317.1 AAS75835.1 BALB/c
    mRNA BC057575.1 None C57BL/6
    mRNA BC082278.1 AAH82278.1
    mRNA HQ698885.1 AEQ34090.1 129X1/SvJ
    mRNA HQ698886.1 AEQ34091.1 A/J
    mRNA HQ698887.1 AEQ34092.1 C57BL/6J
    mRNA HQ698888.1 AEQ34093.1 BALB/cJ
    mRNA HQ698889.1 AEQ34094.1 C3H/HeJ
    mRNA HQ698890.1 AEQ34095.1 LP/J
    mRNA HQ698891.1 AEQ34096.1 RF/J
    mRNA HQ698892.1 AEQ34097.1 SWR/J
    mRNA HQ698893.1 AEQ34098.1 ST/bJ
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TQ92 GenPept UniProtKB/TrEMBL:Q3TQ92
    Q3U3X3 GenPept UniProtKB/TrEMBL:Q3U3X3
    Q3ULX6 GenPept UniProtKB/TrEMBL:Q3ULX6
    Q6R3M4.1 GenPept UniProtKB/Swiss-Prot:Q6R3M4
    Q7TNX7 GenPept UniProtKB/TrEMBL:Q7TNX7
    Q8CF26 GenPept UniProtKB/TrEMBL:Q8CF26
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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