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Nr5a2 nuclear receptor subfamily 5, group A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 26424, updated on 28-May-2016
Official Symbol
Nr5a2provided by MGI
Official Full Name
nuclear receptor subfamily 5, group A, member 2provided by MGI
Primary source
MGI:MGI:1346834
See related
Ensembl:ENSMUSG00000026398 Vega:OTTMUSG00000049882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftf; LRH-1; UF2-H3B; AU020803; D1Ertd308e
Orthologs
Location:
1 59.98 cM; 1 E4
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (136842562..136960448, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (138740161..138857025, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase pseudogene Neighboring gene uncharacterized protein C1orf43 homolog Neighboring gene U7 small nuclear RNA, pseudogene 3 Neighboring gene COP9 (constitutive photomorphogenic) homolog, subunit 8 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bile acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
pancreas morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nuclear receptor subfamily 5 group A member 2
Names
fetoprotein transcription factor
liver receptor homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159769.2NP_001153241.1  nuclear receptor subfamily 5 group A member 2 isoform 2

    See identical proteins and their annotated locations for NP_001153241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) contains a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124814
    Consensus CDS
    CCDS48382.1
    UniProtKB/TrEMBL
    Q1WLP7
    Related
    ENSMUSP00000141495, OTTMUSP00000068639, ENSMUST00000192929, OTTMUST00000127013
    Conserved Domains (2) summary
    cd07069
    Location:259499
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:46138
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
  2. NM_030676.3NP_109601.1  nuclear receptor subfamily 5 group A member 2 isoform 1

    See identical proteins and their annotated locations for NP_109601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC120182, AC124814, BC137845
    Consensus CDS
    CCDS15328.1
    UniProtKB/Swiss-Prot
    P45448
    Related
    ENSMUSP00000027649, OTTMUSP00000068636, ENSMUST00000027649, OTTMUST00000127010
    Conserved Domains (2) summary
    cd07069
    Location:320560
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:107199
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    136842562..136960448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529621.2XP_006529684.1  

    UniProtKB/TrEMBL
    A0A0A6YY04
    Related
    ENSMUSP00000142219, OTTMUSP00000068638, ENSMUST00000192357, OTTMUST00000127012
    Conserved Domains (2) summary
    cd07069
    Location:299539
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:86178
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
  2. XM_006529622.2XP_006529685.1  

    See identical proteins and their annotated locations for XP_006529685.1

    UniProtKB/TrEMBL
    Q1WLP7
    Related
    ENSMUSP00000129071, OTTMUSP00000068637, ENSMUST00000168126, OTTMUST00000127011
    Conserved Domains (2) summary
    cd07069
    Location:259499
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:46138
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    139488247..139612651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)