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Mapk14 mitogen-activated protein kinase 14 [ Mus musculus (house mouse) ]

Gene ID: 26416, updated on 29-May-2016
Official Symbol
Mapk14provided by MGI
Official Full Name
mitogen-activated protein kinase 14provided by MGI
Primary source
MGI:MGI:1346865
See related
Ensembl:ENSMUSG00000053436 Vega:OTTMUSG00000020086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha
Orthologs
Location:
17 A3.3; 17 14.85 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (28691342..28748405)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28828287..28885350)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene solute carrier family 26, member 8 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene Neighboring gene mitogen-activated protein kinase 13 Neighboring gene uncharacterized LOC105246245 Neighboring gene bromodomain and PHD finger containing, 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102436

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
NFAT protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
myoblast differentiation involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
mitogen-activated protein kinase 14
Names
MAP kinase 14
MAP kinase p38 alpha
MAPK 14
cytokine suppressive anti-inflammatory drug binding protein 1
mitogen activated protein kinase 14
mitogen-activated protein kinase p38 alpha
p38 MAP kinase alpha
p38 MAPK
p38 alpha
tRNA synthetase cofactor p38
NP_001161980.1
NP_001161985.1
NP_001161986.1
NP_036081.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168508.1NP_001161980.1  mitogen-activated protein kinase 14 isoform 2

    See identical proteins and their annotated locations for NP_001161980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1. This results in an isoform (2) of the same size, but with a different 27 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC170998, AI132714, AK133684, CX568915, D83073
    Consensus CDS
    CCDS50048.1
    UniProtKB/Swiss-Prot
    P47811
    UniProtKB/TrEMBL
    Q5U421
    Related
    ENSMUSP00000004990, OTTMUSP00000021705, ENSMUST00000004990, OTTMUST00000047771
    Conserved Domains (2) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:24308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_001168513.1NP_001161985.1  mitogen-activated protein kinase 14 isoform 3

    See identical proteins and their annotated locations for NP_001161985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AI132714, AK133684, AK151348
    Consensus CDS
    CCDS50049.1
    UniProtKB/Swiss-Prot
    P47811
    Related
    ENSMUSP00000110400, OTTMUSP00000021709, ENSMUST00000114752, OTTMUST00000047775
    Conserved Domains (2) summary
    smart00220
    Location:1231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001168514.1NP_001161986.1  mitogen-activated protein kinase 14 isoform 3

    See identical proteins and their annotated locations for NP_001161986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an additional exon at the 5' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC170998, AI132714, AK133684
    Consensus CDS
    CCDS50049.1
    UniProtKB/Swiss-Prot
    P47811
    Related
    ENSMUSP00000110402, OTTMUSP00000021707, ENSMUST00000114754, OTTMUST00000047773
    Conserved Domains (2) summary
    smart00220
    Location:1231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
  4. NM_011951.3NP_036081.1  mitogen-activated protein kinase 14 isoform 1

    See identical proteins and their annotated locations for NP_036081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC170998, AI132714, AK133684
    Consensus CDS
    CCDS28583.1
    UniProtKB/Swiss-Prot
    P47811
    Related
    ENSMUSP00000061958, OTTMUSP00000021706, ENSMUST00000062694, OTTMUST00000047772
    Conserved Domains (2) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:24308
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    28691342..28748405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187005.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    1382527..1438986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    29246340..29303175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)