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Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26411, updated on 28-May-2016
Official Symbol
Map4k1provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 1provided by MGI
Primary source
MGI:MGI:1346882
See related
Ensembl:ENSMUSG00000037337 Vega:OTTMUSG00000059210
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpk1; mHPK1
Orthologs
Location:
7; 7 B1
Exon count:
32
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (28982050..29003279)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29767873..29788298)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene predicted gene, 38978 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 38979 Neighboring gene predicted gene, 26604

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase kinase 1
Names
HPK
MAPK/ERK kinase kinase kinase 1
MEK kinase kinase 1
MEKKK 1
hematopoietic progenitor kinase 1
mitogen activated protein kinase kinase kinase kinase 1
NP_032305.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008279.2NP_032305.2  mitogen-activated protein kinase kinase kinase kinase 1

    See identical proteins and their annotated locations for NP_032305.2

    Status: PROVISIONAL

    Source sequence(s)
    AC165142, AC166357
    Consensus CDS
    CCDS39865.1
    UniProtKB/Swiss-Prot
    P70218
    Related
    ENSMUSP00000082995, OTTMUSP00000075712, ENSMUST00000085835, OTTMUST00000145293
    Conserved Domains (3) summary
    smart00036
    Location:506813
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    28982050..29003279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539999.1XP_006540062.1  

    See identical proteins and their annotated locations for XP_006540062.1

    UniProtKB/TrEMBL
    Q3UPT4
    Related
    ENSMUSP00000146807, OTTMUSP00000075711, ENSMUST00000208227, OTTMUST00000145292
    Conserved Domains (3) summary
    smart00036
    Location:460735
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:1228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:1228
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_006539998.2XP_006540061.1  

    Conserved Domains (3) summary
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:506751
    CNH; CNH domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  3. XM_006540000.2XP_006540063.1  

    Related
    ENSMUSP00000147189, OTTMUSP00000075713, ENSMUST00000207185, OTTMUST00000145294
    Conserved Domains (3) summary
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:506733
    CNH; CNH domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  4. XM_006539996.2XP_006540059.1  

    Conserved Domains (3) summary
    smart00036
    Location:506783
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  5. XM_006539997.2XP_006540060.1  

    Conserved Domains (3) summary
    smart00036
    Location:506781
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  6. XM_006539995.2XP_006540058.1  

    Conserved Domains (3) summary
    smart00036
    Location:491798
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    23544299..23565707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)