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Map3k3 mitogen-activated protein kinase kinase kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 26406, updated on 15-May-2016
Official Symbol
Map3k3provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 3provided by MGI
Primary source
MGI:MGI:1346874
See related
Ensembl:ENSMUSG00000020700 Vega:OTTMUSG00000003076
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mekk3; MAPKKK3; AW548911; mKIAA4031
Orthologs
Location:
11; 11 E1
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (106084902..106156656)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105946216..106016760)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene LIM domain containing 2 Neighboring gene STE20-related kinase adaptor alpha Neighboring gene coiled-coil domain containing 47

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4031

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 3
Names
MAPK/ERK kinase kinase 3
MEK kinase 3
MEKK 3
mitogen activated protein kinase kinase kinase 3
NP_036077.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011947.3NP_036077.1  mitogen-activated protein kinase kinase kinase 3

    See identical proteins and their annotated locations for NP_036077.1

    Status: PROVISIONAL

    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS25548.1
    UniProtKB/Swiss-Prot
    Q61084
    Related
    ENSMUSP00000002044, OTTMUSP00000002980, ENSMUST00000002044, OTTMUST00000006328
    Conserved Domains (3) summary
    cd06405
    Location:45123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:362621
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:361621
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    106084902..106156656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249037.1XP_011247339.1  

    Conserved Domains (3) summary
    cd06405
    Location:35113
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:352611
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:351611
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    117815382..117885664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)