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Map2k7 mitogen-activated protein kinase kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 26400, updated on 8-May-2016
Official Symbol
Map2k7provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 7provided by MGI
Primary source
MGI:MGI:1346871
See related
Ensembl:ENSMUSG00000002948 Ensembl:ENSMUSG00000109061 Vega:OTTMUSG00000059344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mek7; Mkk7; sek2; Jnkk2; MEK 7; JNKK 2; Mapkk7; Prkmk7; MAPKK 7; 5930412N11Rik
Orthologs
Location:
8; 8 A1.1
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (4238740..4247897)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (4238740..4247897)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene proline rich 36 Neighboring gene leucine rich repeat containing 8 family, member E Neighboring gene transforming growth factor, beta receptor III-like Neighboring gene small nuclear RNA activating complex, polypeptide 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
JUN kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to UV ISO
Inferred from Sequence Orthology
more info
 
response to heat ISO
Inferred from Sequence Orthology
more info
 
response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
response to stress IDA
Inferred from Direct Assay
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dual specificity mitogen-activated protein kinase kinase 7
Names
JNK kinase 2
JNK-activating kinase 2
MAP kinase kinase 7
MAPK/ERK kinase 7
c-Jun N-terminal kinase kinase 2
map2k7
mitogen activated protein kinase kinase 7
protein kinase, mitogen activated, kinase 7
NP_001036022.1
NP_001157644.1
NP_001278706.1
NP_001278707.1
NP_001278712.1
NP_036074.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042557.2NP_001036022.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_001036022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB005654, BB842920
    Consensus CDS
    CCDS40208.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000003027, OTTMUSP00000017733, ENSMUST00000003027, OTTMUST00000039738
    Conserved Domains (2) summary
    smart00220
    Location:137396
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:120416
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  2. NM_001164172.1NP_001157644.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 3

    See identical proteins and their annotated locations for NP_001157644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains the last intron compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, BB842920, BC070467
    Consensus CDS
    CCDS52474.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000054512, OTTMUSP00000017732, ENSMUST00000062686, OTTMUST00000039737
    Conserved Domains (2) summary
    smart00220
    Location:137396
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:120416
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  3. NM_001291777.1NP_001278706.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 4

    See identical proteins and their annotated locations for NP_001278706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB005654, AK165184, BB842920
    Consensus CDS
    CCDS80852.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106627, OTTMUSP00000022434, ENSMUST00000110999, OTTMUST00000048745
    Conserved Domains (2) summary
    smart00220
    Location:121380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:104400
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  4. NM_001291778.1NP_001278707.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 5

    See identical proteins and their annotated locations for NP_001278707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB005654, AC123029
    Consensus CDS
    CCDS80853.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106623, OTTMUSP00000022436, ENSMUST00000110995, OTTMUST00000048747
    Conserved Domains (2) summary
    smart00220
    Location:48307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:31327
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  5. NM_001291783.1NP_001278712.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 6

    See identical proteins and their annotated locations for NP_001278712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and retains the last intron compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, AF060944, AK049267, BC070467
    Consensus CDS
    CCDS80854.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106622, OTTMUSP00000022435, ENSMUST00000110994, OTTMUST00000048746
    Conserved Domains (2) summary
    smart00220
    Location:48307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:31327
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  6. NM_011944.3NP_036074.2  dual specificity mitogen-activated protein kinase kinase 7 isoform 2

    See identical proteins and their annotated locations for NP_036074.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and retains the last intron compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123029, AK165184, BB842920, CO044477
    Consensus CDS
    CCDS40209.1
    UniProtKB/Swiss-Prot
    Q8CE90
    Related
    ENSMUSP00000106626, OTTMUSP00000017734, ENSMUST00000110998, OTTMUST00000039739
    Conserved Domains (2) summary
    smart00220
    Location:121380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06618
    Location:104400
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    4238740..4247897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    4439329..4448486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)