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Map2k6 mitogen-activated protein kinase kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 26399, updated on 8-May-2016
Official Symbol
Map2k6provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 6provided by MGI
Primary source
MGI:MGI:1346870
See related
Ensembl:ENSMUSG00000020623 Vega:OTTMUSG00000003325
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MEK6; MKK6; Prkmk6; SAPKK3
Orthologs
Location:
11; 11 E1
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (110399102..110516212)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (110260436..110374951)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 5 Neighboring gene predicted gene, 39445 Neighboring gene predicted gene, 39446 Neighboring gene predicted gene, 30009 Neighboring gene predicted gene 11682

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IPI
Inferred from Physical Interaction
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dual specificity mitogen-activated protein kinase kinase 6
Names
MAP kinase kinase 6
MAPK/ERK kinase 6
MAPKK 6
MEK 6
mitogen activated protein kinase kinase 6
protein kinase, mitogen activated, kinase 6
NP_036073.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011943.2NP_036073.1  dual specificity mitogen-activated protein kinase kinase 6

    See identical proteins and their annotated locations for NP_036073.1

    Status: PROVISIONAL

    Source sequence(s)
    AK043482
    Consensus CDS
    CCDS25592.1
    UniProtKB/Swiss-Prot
    P70236
    UniProtKB/TrEMBL
    Q543Z5
    Related
    ENSMUSP00000020949, OTTMUSP00000003317, ENSMUST00000020949, OTTMUST00000006983
    Conserved Domains (2) summary
    cd06617
    Location:51333
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:54314
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    110399102..110516212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249034.1XP_011247336.1  

    Conserved Domains (2) summary
    cd06617
    Location:91373
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:94354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_011249036.1XP_011247338.1  

    See identical proteins and their annotated locations for XP_011247338.1

    UniProtKB/TrEMBL
    Q60521
    Conserved Domains (2) summary
    smart00220
    Location:7217
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1236
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011249035.1XP_011247337.1  

    See identical proteins and their annotated locations for XP_011247337.1

    Conserved Domains (2) summary
    cd06617
    Location:1264
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:2245
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_006533378.2XP_006533441.1  

    See identical proteins and their annotated locations for XP_006533441.1

    Conserved Domains (2) summary
    cd06617
    Location:1264
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:2245
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. XM_006533377.2XP_006533440.1  

    See identical proteins and their annotated locations for XP_006533440.1

    Conserved Domains (2) summary
    cd06617
    Location:1264
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:2245
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  6. XM_006533376.2XP_006533439.1  

    Conserved Domains (2) summary
    cd06617
    Location:51333
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:54314
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    122139172..122253133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)