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Map2k2 mitogen-activated protein kinase kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 26396, updated on 28-May-2016
Official Symbol
Map2k2provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 2provided by MGI
Primary source
MGI:MGI:1346867
See related
Ensembl:ENSMUSG00000035027 Vega:OTTMUSG00000016975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MK2; MEK2; Prkmk2; AA589381
Orthologs
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (81105912..81124697)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80568692..80587442)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 3 Neighboring gene microRNA 5615-1 Neighboring gene microRNA 5615-2 Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
epithelial cell proliferation involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
face development IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
early endosome TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
focal adhesion TAS
Traceable Author Statement
more info
PubMed 
late endosome TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dual specificity mitogen-activated protein kinase kinase 2
Names
ERK activator kinase 2
MAP kinase kinase 2
MAP kinase/Erk kinase
MAPK/ERK kinase 2
MAPKK 2
MEK 2
mitogen activated protein kinase kinase 2
protein kinase, mitogen activated, kinase 2, p45
NP_075627.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023138.4NP_075627.2  dual specificity mitogen-activated protein kinase kinase 2

    See identical proteins and their annotated locations for NP_075627.2

    Status: VALIDATED

    Source sequence(s)
    AK009392, AK036822, AK080574, AK140101, BE955857
    Consensus CDS
    CCDS24044.1
    UniProtKB/Swiss-Prot
    Q63932
    UniProtKB/TrEMBL
    Q3USU3, Q8CB46
    Related
    ENSMUSP00000121111, OTTMUSP00000018442, ENSMUST00000143517, OTTMUST00000041162
    Conserved Domains (2) summary
    cd06615
    Location:70388
    PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
    smart00220
    Location:72370
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    81105912..81124697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513684.2XP_006513747.1  

    See identical proteins and their annotated locations for XP_006513747.1

    Conserved Domains (2) summary
    smart00220
    Location:1179
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1206
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006513682.2XP_006513745.1  

    See identical proteins and their annotated locations for XP_006513745.1

    UniProtKB/TrEMBL
    Q91YS7
    Related
    ENSMUSP00000100968, OTTMUSP00000018443, ENSMUST00000105331, OTTMUST00000041163
    Conserved Domains (2) summary
    cd06615
    Location:70387
    PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
    smart00220
    Location:72369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_006513683.2XP_006513746.1  

    Conserved Domains (2) summary
    smart00220
    Location:1180
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1207
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    82126303..82145053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)