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Axl AXL receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 26362, updated on 30-May-2016
Official Symbol
Axlprovided by MGI
Official Full Name
AXL receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1347244
See related
Ensembl:ENSMUSG00000002602 Vega:OTTMUSG00000022291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ark; Ufo; Tyro7; AI323647
Orthologs
Location:
7 14.02 cM; 7 A3-B1
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (25756500..25788733, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26542292..26573560, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
enzyme linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
erythrocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
host cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein kinase receptor UFO
Names
adhesion-related kinase
ufo oncogene homolog
NP_001177903.1
NP_001177904.1
NP_033491.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190974.1NP_001177903.1  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614, AK033237, BC058230
    Consensus CDS
    CCDS57528.1
    UniProtKB/TrEMBL
    Q6PE80, Q8CCF8
    Related
    ENSMUSP00000083110, OTTMUSP00000025230, ENSMUST00000085948, OTTMUST00000053094
    Conserved Domains (8) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:521788
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14316
    Location:416466
    DUF4381; Domain of unknown function (DUF4381)
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. NM_001190975.1NP_001177904.1  tyrosine-protein kinase receptor UFO isoform 3 precursor

    See identical proteins and their annotated locations for NP_001177904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614
    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00221
    Location:435700
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. NM_009465.4NP_033491.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See identical proteins and their annotated locations for NP_033491.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC119211, AC162614, AK033237, BC050914
    Consensus CDS
    CCDS20996.1
    UniProtKB/Swiss-Prot
    Q00993
    UniProtKB/TrEMBL
    Q8CCF8
    Related
    ENSMUSP00000002677, OTTMUSP00000025228, ENSMUST00000002677, OTTMUST00000053091
    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:530797
    Pkinase_Tyr; Protein tyrosine kinase
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    25756500..25788733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539993.2XP_006540056.1  

    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00221
    Location:426691
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:423699
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. XM_006539990.1XP_006540053.1  

    See identical proteins and their annotated locations for XP_006540053.1

    UniProtKB/Swiss-Prot
    Q00993
    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:530797
    Pkinase_Tyr; Protein tyrosine kinase
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. XM_006539992.1XP_006540055.1  

    See identical proteins and their annotated locations for XP_006540055.1

    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00221
    Location:435700
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  4. XM_006539991.2XP_006540054.1  

    See identical proteins and their annotated locations for XP_006540054.1

    UniProtKB/TrEMBL
    Q6PE80
    Conserved Domains (8) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:521788
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14316
    Location:416466
    DUF4381; Domain of unknown function (DUF4381)
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  5. XM_006539989.2XP_006540052.1  

    See identical proteins and their annotated locations for XP_006540052.1

    UniProtKB/Swiss-Prot
    Q00993
    Conserved Domains (7) summary
    cd00096
    Location:47120
    Ig; Immunoglobulin domain
    smart00409
    Location:35114
    IG; Immunoglobulin
    smart00410
    Location:139217
    IG_like; Immunoglobulin like
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:530797
    Pkinase_Tyr; Protein tyrosine kinase
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cl11960
    Location:135216
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    20365412..20397704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)