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    GNL3 guanine nucleotide binding protein-like 3 (nucleolar) [ Homo sapiens ]

    Gene ID: 26354, updated on 20-May-2012
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    Summary

    Official Symbol
    GNL3provided by HGNC
    Official Full Name
    guanine nucleotide binding protein-like 3 (nucleolar)provided by HGNC
    Primary source
    HGNC:29931
    See related
    Ensembl:ENSG00000163938; HPRD:06419; MIM:608011; Vega:OTTHUMG00000158752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS; E2IG3; NNP47; C77032; MGC800
    Summary
    The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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    Genomic context

    Location :
    3p21.1
    Sequence :
    Chromosome: 3; NC_000003.11 (52719936..52728513)
    See GNL3 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 78 Neighboring gene polybromo 1 Neighboring gene small nucleolar RNA, C/D box 19B Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene zinc finger protein 610 pseudogene Neighboring gene NIMA (never in mitosis gene a)-related kinase 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion. Lo D, et al. J Biol Chem, 2012 Mar 23. PMID 22318725.
    2. An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells. Gil-Ranedo J, et al. PLoS One, 2011. PMID 22174890.
    3. Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma. Nakajima TE, et al. Cancer Sci, 2012 Feb. PMID 22050045.
    4. Nucleostemin inhibits TRF1 dimerization and shortens its dynamic association with the telomere. Meng L, et al. J Cell Sci, 2011 Nov 1. PMID 22045740.
    5. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.

    See all (60) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NS undergoes a ubiquitin- and MDM2-independent proteasomal degradation when intracellular GTP levels are markedly reduced
      Title: Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion.
    2. Nucleostemin is expressed in Glioblastoma-cancer stem cells isolated from patient samples, and that its expression, conversely to what it has been described for ordinary stem cells, does not disappear when cells are differentiated.
      Title: An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
    3. nucleostemin expression level correlated with TWIST expression level in esophageal cancer cell lines; identified that high nucleostemin proportion, TWIST intensity, and advanced pathological N stage were correlated with poor relapse-free survival
      Title: Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma.
    4. NS inhibits TRF1 dimerization and shortens TRF1 association with the telomere.
      Title: Nucleostemin inhibits TRF1 dimerization and shortens its dynamic association with the telomere.
    5. a complex composed of TERT, BRG1, and NS/GNL3L maintains the function of tumor initiating cells
      Title: Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.
    6. expression in ovarian tumors closely correlated with origination, progression, and grading
      Title: Clinical significance of nucleostemin expression and its correlation with cyclin D1 expression in malignant ovarian tumors.
    7. Telomere length in Sjogren syndrome is shorter and associated with lower levels of expression of p63 and nucleostemin than in non-Sjogren syndrome.
      Title: Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjögren syndrome and non-Sjögren syndrome dry eye patients.
    8. NS is widely expressed in normal and neoplastic oral epithelial tissues, and is likely a marker of proliferation
      Title: Nucleostemin affects the proliferation but not differentiation of oral squamous cell carcinoma cells.
    9. Apoptosis of HL-60 leukemia cells can be induced by silencing NS gene expression.
      Title: [Effects of silent nucleostemin gene expression on apoptosis of HL-60 cells in vitro].
    10. Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
      Title: Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
    Submit: New GeneRIF Correction See all (38)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BVP2 Q9H1I8 ASCC2    HPRD  PubMed  
    Q9BVP2 Q15172 PPP2R5A    HPRD  PubMed  
    Q9BVP2 P04637 TP53    HPRD  PubMed  
    BioGRID:117690 BioGRID:123921 ASCC2    BioGRID  PubMed Two-hybrid 
    BioGRID:117690 BioGRID:124082 DOT1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117690 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:110994 OAS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117690 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:212920 Sgol2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117690 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117690 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117690 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    guanine nucleotide-binding protein-like 3
    Names
    guanine nucleotide-binding protein-like 3
    nucleostemin
    E2-induced gene 3 protein
    novel nucleolar protein 47
    nucleolar GTP-binding protein 3
    estradiol-induced nucleotide binding protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027871.1 RefSeqGene

      Range
      5001..13578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014366.4 → NP_055181.3  guanine nucleotide-binding protein-like 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI028402, AK027514, BC001024, CF272475
      Consensus CDS
      CCDS2861.1
      UniProtKB/Swiss-Prot
      Q9BVP2
      Related
      ENSP00000395772, OTTHUMP00000213382, ENST00000418458, OTTHUMT00000352032
      Conserved Domains (2) summary
      pfam08701
      Location:16 – 56
      Blast Score: 168
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
      cd04178
      Location:142 – 307
      Blast Score: 689
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

    2. NM_206825.1 → NP_996561.1  guanine nucleotide-binding protein-like 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AF191018, AI028402, AK027514
      Consensus CDS
      CCDS43100.1
      UniProtKB/Swiss-Prot
      Q9BVP2
      Related
      ENSP00000378278, OTTHUMP00000213383, ENST00000394799, OTTHUMT00000352033
      Conserved Domains (2) summary
      pfam08701
      Location:4 – 44
      Blast Score: 173
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
      cd04178
      Location:130 – 295
      Blast Score: 692
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

    3. NM_206826.1 → NP_996562.1  guanine nucleotide-binding protein-like 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AF191018, AK027514, BC001024, BF732788
      Consensus CDS
      CCDS43100.1
      UniProtKB/Swiss-Prot
      Q9BVP2
      Conserved Domains (2) summary
      pfam08701
      Location:4 – 44
      Blast Score: 173
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
      cd04178
      Location:130 – 295
      Blast Score: 692
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      52719936..52728513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      52781776..52790367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104446.2 (138683..147260) None
    genomic CH471055.1 EAW65249.1
      EAW65250.1
      EAW65251.1
      EAW65252.1
    mRNA AF191018.1 AAF09482.1
    mRNA AI028402.1 None
    mRNA AK027514.1 BAB55168.1
    mRNA AK027516.1 BAB55169.1
    mRNA AK315484.1 BAG37868.1
    mRNA AY825265.1 AAV74413.1
    mRNA BC001024.2 AAH01024.1
    mRNA BF732788.1 None
    mRNA CF272475.1 None
    other-genetic EU831969.1 ACE87410.1
    other-genetic EU832062.1 ACE86724.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BVP2.2 GenPept UniProtKB/Swiss-Prot:Q9BVP2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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